Evidence map›Paper›PMID 34837879›Full record

ArticleThe International journal on drug policy2022

Simulating the impact of Addiction Consult Services in the context of drug supply contamination, hospitalizations, and drug-related mortality.

Caroline A King, Ryan Cook, Haven Wheelock, P Todd Korthuis, Judith M Leahy, Amelia Goff, Cynthia D Morris, Honora Englander

Abstract read
In one paragraph

Article in The International journal on drug policy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caroline A KingDept. of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, USA. Electronic address: kingca@ohsu.edu.
Ryan CookDept. of Medicine, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, USA.
Haven WheelockOutside In, Portland, OR, USA.
P Todd KorthuisDept. of Medicine, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, USA.
Judith M LeahyOregon Health Authority, Acute and Communicable Disease Prevention, Public Health Division, Oregon Health Authority, Salem, OR, USA.
Amelia GoffDept. of Medicine, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, USA; Division of Hospital Medicine, Department of Medicine, Oregon Health & Science University, Portland, OR, USA.
Cynthia D MorrisDept. of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR, USA.
Honora EnglanderDept. of Medicine, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, USA; Division of Hospital Medicine, Department of Medicine, Oregon Health & Science University, Portland, OR, USA.

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Western States Node of the National Drug Abuse Treatment Clinical Trials Network (TMS for CUD) UG1DA015815 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Keith N. Humphreys, Philip Todd Korthuis · 2015 to 2026
$24.6M
Oregon Clinical and Translational Research Institute TL1 ProgramTL1TR002371 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALLISON Deborah FRYER, JESSINA C MCGREGOR · 2017 to 2026
$6.2M
Oregon HIV/Hepatitis and Opioid Prevention and Engagement (OR-HOPE) Study Cost ExtensionUH3DA044831 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KORTHUIS, PHILIP TODD · 2019 to 2022
$4.0M
Modeling the impact of hospital-based addiction consult services on post-discharge mortalityF30DA052972 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KING, CAROLINE · 2021 to 2021
$36k
NCATS NIH HHS TL1 TR002371NCATS NIH HHS UL1 TR002369NIDA NIH HHS F30 DA052972NIDA NIH HHS UG1 DA015815NIDA NIH HHS UH3 DA044831
6 · The paper itself

Abstract

backgroundIllicitly manufactured fentanyl (IMF) is increasing in international drug supply chains, and IMF-related opioid overdose deaths are rising in North America. Hospitalizations among patients with opioid use disorder (OUD) are also rising; and, hospitalized patients are at increased risk of overdose and death following hospital discharge. Hospitalization is a key opportunity to engage patients with OUD. Addiction consult services (ACS) can provide effective treatment for patients hospitalized with OUD. This study aims to estimate the effect of increasing IMF contamination on drug-related death among patients hospitalized with OUD, and simulate the role of ACS expansion to mitigate these effects.

methodsWe used a Markov model to mirror care systems for adult patients hospitalized with OUD in Oregon, from the time of hospital admission through 12-months post-discharge, and simulated patients through modeled care systems to evaluate the expansion of Addiction Consult Services in the context of increasing IMF in the drug supply.

resultsIn a simulated cohort of 10,000 patients, we estimate that 537 patients would die from drug-related causes within 12-months of hospital discharge. In the context of increased IMF in the drug supply, this estimate increased to 913. ACS referral at baseline was 4%; increasing ACS referral to accommodate 10%, 50%, or 100% of hospitalized OUD patients in the state reduces drug-related deaths to 904, 849, and 780, respectively. The number needed to treat for ACS to avoid one drug-related death in the context of increased IMF was 73.

conclusionsHospitals should expand interventions to help reduce IMF-related opioid overdoses, including through implementation of ACS. In the context of rising IMF-related deaths, ACS expansion could help connect patients to treatment, offer harm reduction interventions, or both, which can help reduce the risk of opioid-related death.

Indexed as

Drug OverdoseOpioid-Related DisordersAdultAftercareAnalgesics, OpioidFentanylHospitalizationHumansPatient DischargeReferral and ConsultationAnalgesics, OpioidFentanylDrug overdoseFentanylHarm ReductionHospitalizationOpioid-related disordersPatient Discharge

Identifiers

PMID34837879
PMCPMC8810590

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.