ArticleCancer medicine2022
Noninvasive preoperative differential diagnosis of gallbladder carcinoma and xanthogranulomatous cholecystitis: A retrospective cohort study of 240 patients.
Article in Cancer medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 13 citations in OpenAlex.
- The Diagnostic Mirage: Xanthogranulomatous Cholecystitis and the Illusion of Gallbladder Carcinoma.Cureus · 2026Article
- Management of Extensive Xanthogranulomatous Cholecystitis Lesions: A Case Report.The American journal of case reports · 2026Article
- The Challenging Management of Gallbladder Masses: A Case of Xanthogranulomatous Cholecystitis and Diffuse Biliary Hamartomatosis Mimicking Gallbladder Metastatic Cancer.Case reports in surgery · 2026Article
- Machine learning model for differentiating xanthogranulomatous cholecystitis and gallbladder cancer in multicenter largescale study.NPJ digital medicine · 2025Article
- Establishment and validation of a novel prognostic nomogram for gallbladder cancer patients.European journal of medical research · 2025Article
- 18F-FDG PET/CT in xanthogranulomatous cholecystitis with CA199 elevation: diagnostic dilemmas and differentiation strategies.Frontiers in medicine · 2025Article
- Radiological Findings for Distinguishing Between Xanthogranulomatous Cholecystitis and Gallbladder Cancer.Archives of Iranian medicine · 2024Article
- Xanthogranulomatous Cholecystitis: A Retrospective Review of Clinical Diagnosis and Treatment from a Single Center.Healthcare (Basel, Switzerland) · 2024Article
- Deep-learning models for differentiation of xanthogranulomatous cholecystitis and gallbladder cancer on ultrasound.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Article
- Machine learning-based diagnostic model for preoperative differentiation between xanthogranulomatous cholecystitis and gallbladder carcinoma: a multicenter retrospective cohort study.Frontiers in oncology · 2024Article
- Gallbladder cancer masquerading as xanthogranulomatous cholecystitis: a case report and literature review.Frontiers in oncology · 2024Article
- Differential diagnoses of gallbladder tumors using CT-based deep learning.Annals of gastroenterological surgery · 2022Article
- Noninvasive preoperative differential diagnosis of gallbladder carcinoma and xanthogranulomatous cholecystitis: A retrospective cohort study of 240 patients.Cancer medicine · 2022Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundXanthogranulomatous cholecystitis (XGC) is an extremely rare entity. Due to XGC's clinical and radiological resemblance to gallbladder carcinoma (GBC), intraoperative frozen section during cholecystectomy is often performed to exclude the diagnosis of GBC. Our study is aiming to find a noninvasive indicator of XGC. To our knowledge, this is the largest XGC cohort ever studied.
methodsThis study retrospectively collected clinical characteristics, serological tests, and imaging features of 150 GBC patients and 90 XGC patients. The diagnosis of these 150 GBC patients and 90 XGC patients was based on intraoperative frozen section histopathology. T-test was utilized to compare differences between XGC and GBC. Receiver operating characteristic (ROC) curve was conducted and the area under the curve (AUC) was managed to evaluate the validity.
resultsThe carcinoembryonic antigen (CEA) level in blood tests was significantly elevated in GBC patients than in XGC patients (p = 0.007). The presence of submucosal hypo-attenuated nodules (80% in XGC, 16% in GBC, p < 0.001), low density border (60% in XGC, 21% in GBC, p = 0.001), and nodular thickening in the bottom of the gallbladder with calcification (70% in XGC, 37% in GBC, p = 0.004) is significantly associated with XGC patients, whereas massive hilar infiltration (0% in XGC, 21% in GBC, p < 0.001), multiple lymph nodes in the hilar area (10% in XGC, 72% in GBC, p = 0.001), and gallbladder mucosal line continuity (50% in XGC, 95% in GBC, p = 0.002) are highly associated with GBC patients. The ROC curve was performed and the gallbladder mucosal line continuity (AUC = 0.708) and the AUC of low density border around the occupation (AUC = 0.654) showed a good prediction of XGC.
conclusionsGallbladder mucosal line continuity and low density border around the occupation presented good indication value for the diagnosis of XGC. Our study proposed a noninvasive differential diagnosis method for XGC and GBC.
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