Evidence map›Paper›PMID 34837212›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Cationic Contrast Agents for Computed Tomography of Cartilage for Early Diagnosis of Osteoarthritis.

Chenzhen Zhang, Ambika G Bajpayee

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Chenzhen ZhangDepartment of Bioengineering, Northeastern University, Boston, MA, USA.
Ambika G BajpayeeDepartment of Bioengineering, Northeastern University, Boston, MA, USA. a.bajpayee@northeastern.edu.
Northeastern University · US

Funding

Anti-catabolic drug anchored cationic exosomes for cartilage targeting and repairR21EB028385 · NIBIB · NORTHEASTERN UNIVERSITY · PI BAJPAYEE, AMBIKA GOEL · 2019 to 2021
$628k
Charge driven contrast enhanced computed tomography for imaging negatively charged tissuesR03EB025903 · NIBIB · NORTHEASTERN UNIVERSITY · PI BAJPAYEE, AMBIKA GOEL · 2018 to 2019
$157k
NIBIB NIH HHS R03 EB025903NIBIB NIH HHS R21 EB028385
6 · The paper itself

Abstract

Here we describe methods for synthesizing cationic contrast agents for computed tomography (CT) of cartilage for early diagnosis of tissue degeneration. CT imaging of soft tissues like cartilage is possible only if radio-opaque contrast agents (e.g., ioxaglate) can penetrate through the full thickness of tissue in sufficient concentrations. Ioxaglate (IOX), however, is anionic and is repelled by the negatively charged cartilage matrix resulting in poor CT attenuation. Here we demonstrate cartilage penetrating cationic contrast agents using multi-arm Avidin (mAv) conjugated to ioxaglate (mAv-IOX). mAv-IOX rapidly penetrates through the full thickness of cartilage in high concentrations owing to weak-reversible nature of electrostatic interactions resulting in high CT attenuation even with low doses unlike IOX. The technology has the potential for enabling clinical CT of cartilage and other negatively charged soft tissues.

Indexed as

OsteoarthritisAvidinCartilage, ArticularCationsContrast MediaEarly DiagnosisHumansIoxaglic AcidTomography, X-Ray ComputedAvidinCationsContrast MediaIoxaglic AcidAvidinBio-electrostaticsCartilageCationic contrast agentsComputed tomography (CT)IoxaglateNegatively charged tissues

Identifiers

PMID34837212
OpenAlexW3214945666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.