Evidence map›Paper›PMID 34837200›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Mixed Modeling Frameworks for Analyzing Whole-Brain Network Data.

Sean L Simpson

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Statistical Brain Network Analysis.Annual review of statistics and its application · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Sean L SimpsonDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA. slsimpso@wakehealth.edu.

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Analytical Tools for Complex Brain Networks: Fusing Novel Statistical Methods and Network Science to Understand Brain FunctionR01EB024559 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SIMPSON, SEAN L · 2018 to 2021
$1.5M
NCATS NIH HHS UL1 TR001420NIBIB NIH HHS R01 EB024559
6 · The paper itself

Abstract

Brain network analyses have exploded in recent years and hold great potential in helping us understand normal and abnormal brain function. Network science approaches have facilitated these analyses and our understanding of how the brain is structurally and functionally organized. However, the development of statistical methods that allow relating this organization to health outcomes has lagged behind. We have attempted to address this need by developing mixed modeling frameworks that allow relating system-level properties of brain networks to outcomes of interest. These frameworks serve as a synergistic fusion of multivariate statistical approaches with network science, providing a needed analytic (modeling and inferential) foundation for whole-brain network data. In this chapter we delineate these approaches that have been developed for single-task and multitask (longitudinal) brain network data, illustrate their utility with data applications, detail their implementation with a user-friendly Matlab toolbox, and discuss ongoing work to adapt the methods to (within-task) dynamic network analysis.

Indexed as

BrainBrain MappingMagnetic Resonance ImagingBrain networksConnectivityfMRIGraph theoryMatlab toolboxMixed model

Identifiers

PMID34837200
PMCPMC9251854

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.