Evidence map›Paper›PMID 34837150›Full record

ArticleMolecular biology reports2022

miR-1290 promotes IL-8-mediated vascular endothelial cell adhesion by targeting GSK-3β.

Hongxin Xu, Ying Cui, Xianwei Liu, Xiao Zheng, Jiaqing Liu, Xinxin Hu, Fuhua Gao, Xiaoyan Hu, Mei Li, Xiaoqing Wei and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. An Insight into miR-1290: An Oncogenic miRNA with Diagnostic Potential.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Hongxin Xu *Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Ying Cui *Molecular Medical Laboratory, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Xianwei LiuDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Xiao ZhengDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Jiaqing LiuDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Xinxin HuDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Fuhua GaoDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Xiaoyan HuDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Mei LiDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Xiaoqing WeiMolecular Medical Laboratory, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Ying GaoLiaoning Provincial Core Lab of Medical Molecular Biology, Dalian Medical University, Dalian, China. gaoying200018@126.com.
Ying ZhaoMolecular Medical Laboratory, College of Basic Medical Science, Dalian Medical University, Dalian, China. zhaoying20001105@126.com.
Dalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicroRNA-1290 (miR-1290) has been reported to be involved in many diseases and play a key role during the development process. However, the role of miR-1290 in atherosclerosis (AS) is still unclear. METHODS AND

resultsThe current study showed that the expressions of miR-1290 were high in serum of patients with hyperlipidemia. The functional role of miR-1290 were then investigated in human umbilical vein endothelial cells (HUVECs). Here, we found that miR-1290 expressions were notably enhanced in HUVECs mediated by IL-8. miR-1290 inhibitor repressed monocytic THP-1 cells adhesion to HUVECs by regulating ICAM-1 and VCAM-1, inhibited proliferation through regulating cyclinD1 and PCNA, and inhibited inflammatory response by regulating IL-1β. Mechanistically, we verified that miR-1290 mimic was able to directly target the 3'-UTR of GSK-3β mRNA using luciferase reporter assay. Knockdown of GSK-3β (si-GSK-3β) promoted HUVECs adhesion and the expression of IL-1β, and partially restore the depression effect of miR-1290 inhibitor on HUVECs adhesion and inflammation. In contrast, si-GSK-3β inhibited the proliferation of HUVECs and the expression of cyclinD1 and PCNA.

conclusionsIn summary, our study revealed that miR-1290 promotes IL-8-mediated the adhesion of HUVECs by targeting GSK-3β. However, GSK-3β is not the target protein for miR-1290 to regulate the proliferation of HUVECs. Our findings may provide potential target in atherosclerosis treatment.

Indexed as

Interleukin-8MicroRNAsApoptosisCell ProliferationGlycogen Synthase Kinase 3 betaHumansHuman Umbilical Vein Endothelial CellsCXCL8 protein, humanGlycogen Synthase Kinase 3 betaGSK3B protein, humanInterleukin-8MicroRNAsMIRN1290 microRNA, humanAdhesionGSK-3βHUVECsmiR-1290

Identifiers

PMID34837150
OpenAlexW3214771129

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.