Evidence map›Paper›PMID 34837029›Full record

ArticleScientific reports2021

The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study.

Eirin B Haug, Amanda R Markovitz, Abigail Fraser, Håvard Dalen, Pål R Romundstad, Bjørn O Åsvold, Janet W Rich-Edwards, Julie Horn

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Vascular Health of Females with History of Assisted Reproductive Technology.Journal of cardiovascular development and disease · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eirin B HaugDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Postboks 8905, 7491, Trondheim, Norway. eirin.haug@ntnu.no.
Amanda R MarkovitzDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Abigail FraserDepartment of Population Health Sciences, Bristol Medical School and MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Håvard DalenDepartment of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.
Pål R RomundstadDepartment of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Bjørn O ÅsvoldDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Postboks 8905, 7491, Trondheim, Norway.
Janet W Rich-EdwardsDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Julie HornDepartment of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Funding

Predoctoral Training Program in Reproductive, Perinatal & Pediatric EpidemiologyT32HD060454 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI MICHELS, KARIN B · 2010 to 2014
$1.1M
American Heart Association 16PRE29690006Eunice Kennedy Shriver National Institute of Child Health and Human Development T32HD060454Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_12013/5Medical Research Council MR/M009351/1NICHD NIH HHS T32 HD060454Norges Forskningsråd 231149/F20
6 · The paper itself

Abstract

A history of preterm or small (SGA) or large (LGA) for gestational age offspring is associated with smoking and unfavorable levels of BMI, blood pressure, glucose and lipids. Whether and to what extent the excess cardiovascular risk observed in women with these pregnancy complications is explained by conventional cardiovascular risk factors (CVRFs) is not known. We examined the association between a history of SGA, LGA or preterm birth and cardiovascular disease among 23,284 parous women and quantified the contribution of individual CVRFs to the excess cardiovascular risk using an inverse odds weighting approach. The hazard ratios (HR) between SGA and LGA offspring and CVD were 1.30 (95% confidence interval (CI) 1.15, 1.48) and 0.89 (95% CI 0.76, 1.03), respectively. Smoking explained 49% and blood pressure may have explained ≈12% of the excess cardiovascular risk in women with SGA offspring. Women with preterm birth had a 24% increased risk of CVD (HR 1.24, 95% CI 1.06, 1.45), but we found no evidence for CVRFs explaining any of this excess cardiovascular risk. While smoking explains a substantial proportion of excess cardiovascular risk in women with SGA offspring and blood pressure may explain a small proportion in these women, we found no evidence that conventional CVRFs explain any of the excess cardiovascular risk in women with preterm birth.

Indexed as

Heart Disease Risk FactorsAdultCardiovascular DiseasesFemaleFetal MacrosomiaGestational AgeHumansInfant, NewbornInfant, Small for Gestational AgeLongitudinal StudiesPregnancyPregnancy ComplicationsPremature BirthYoung Adult

Identifiers

PMID34837029
PMCPMC8626478

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.