Evidence map›Paper›PMID 34836998›Full record

ArticleScientific reports2021

Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report.

Amritpal S Bhullar, Irma Magaly Rivas-Serna, Ana Anoveros-Barrera, Abha Dunichand-Hoedl, David Bigam, Rachel G Khadaroo, Todd McMullen, Oliver Bathe, Charles T Putman, Vickie Baracos and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Amritpal S BhullarDepartment of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research Innovation, 8602-112 St NW, Edmonton, AB, Canada.
Irma Magaly Rivas-SernaDepartment of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research Innovation, 8602-112 St NW, Edmonton, AB, Canada.
Ana Anoveros-BarreraDepartment of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research Innovation, 8602-112 St NW, Edmonton, AB, Canada.
Abha Dunichand-HoedlDepartment of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research Innovation, 8602-112 St NW, Edmonton, AB, Canada.
David BigamDepartment of Surgery, University of Alberta, Edmonton, Canada.
Rachel G KhadarooDepartment of Surgery, University of Alberta, Edmonton, Canada.
Todd McMullenDepartment of Surgery, University of Alberta, Edmonton, Canada.
Oliver BatheDepartments of Surgery and Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Canada.
Charles T PutmanFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Canada.
Vickie BaracosDepartment of Oncology, University of Alberta, Edmonton, Canada.
Michael T ClandininDepartment of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research Innovation, 8602-112 St NW, Edmonton, AB, Canada.
Vera C MazurakDepartment of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research Innovation, 8602-112 St NW, Edmonton, AB, Canada. vera.mazurak@ualberta.ca.
University of Alberta · CAUniversity of Calgary · CA

Funding

CIHR
6 · The paper itself

Abstract

Emerging studies are reporting associations between skeletal muscle abnormalities and survival in cancer patients. Cancer prognosis is associated with depletion of essential fatty acids in erythrocytes and plasma in humans. However the relationship between skeletal muscle membrane fatty acid composition and survival is unknown. This study investigates the relationship between fatty acid content of phospholipids in skeletal muscle and survival in cancer patients. Rectus abdominis biopsies were collected during cancer surgery from 35 patients diagnosed with cancer. Thin-layer and gas chromatography were used for quantification of phospholipid fatty acids. Cutpoints for survival were defined using optimal stratification. Median survival was between 450 and 500 days when patients had arachidonic acid (AA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in muscle phospholipid below the cut-point compared to 720-800 days for patients above. Cox regression analysis revealed that low amounts of AA, EPA and DHA are risk factors for death. The risk of death remained significant for AA [HR 3.5 (1.11-10.87), p = 0.03], EPA [HR 3.92 (1.1-14.0), p = 0.04] and DHA [HR 4.08 (1.1-14.6), p = 0.03] when adjusted for sex. Lower amounts of essential fatty acids in skeletal muscle membrane is a predictor of survival in cancer patients. These results warrant investigation to restore bioactive fatty acids in people with cancer.

Indexed as

AgedArachidonic AcidDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, EssentialFemaleHumansMaleMiddle AgedNeoplasmsProportional Hazards ModelsRectus AbdominisRisk FactorsSurvival AnalysisArachidonic AcidDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Essential

Identifiers

PMID34836998
PMCPMC8626431
OpenAlexW3216653516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.