ArticleNature communications2021
Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Acetylcholine and noradrenaline enhance foraging optimality in humans.Proceedings of the National Academy of Sciences of the United States of America · 2023Trial
- The role of subcortical brain tissue iron as an indicator of dopamine neurophysiology in adolescent cannabis use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
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- Sex-specific behavioral and monoaminergic network alterations following adolescent binge-like ethanol and WIN55,212-2 exposure under chronic nicotine in rats.Frontiers in pharmacology · 2026Article
- Proposed mechanisms of neuroprotection for nicotine in Parkinson's disease.Journal of Parkinson's disease · 2025Review
- Influence of oral health on smoking cessation intention in current smokers with insights from a nationally representative survey.Scientific reports · 2025Article
- Reversed-Phase (RP) and Hydrophilic Interaction (HILIC) Separation Mechanisms for the Assay of Nicotine and E-Cigarette Liquids.Molecules (Basel, Switzerland) · 2025Article
- Direct and indirect striatal projecting neurons exert strategy-dependent effects on decision-making.Science advances · 2025Article
- Dopamine builds and reveals reward-associated latent behavioral attractors.Nature communications · 2024Article
- Individualistic reward-seeking strategies that predict response to nicotine emerge among isogenic male mice living in a micro-society.PLoS biology · 2024Article
- Article
- A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use.bioRxiv : the preprint server for biology · 2024Article
- Simulated synapse loss induces depression-like behaviors in deep reinforcement learning.Frontiers in computational neuroscience · 2024Article
- Article
- Effect of Cigarette Smoke Exposure and Aspirin Treatment on Neurotransmitters' Tissue Content in Rats' Hippocampus and Amygdala.Metabolites · 2023Article
- Microglia sustain anterior cingulate cortex neuronal hyperactivity in nicotine-induced pain.Journal of neuroinflammation · 2023Article
- Machine learning models for predicting depression in Korean young employees.Frontiers in public health · 2023Article
- Social Determinants of Inter-Individual Variability and Vulnerability: The Role of Dopamine.Frontiers in behavioral neuroscience · 2022Review
Corrections and comments
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Authors and funding
19 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term exposure to nicotine alters brain circuits and induces profound changes in decision-making strategies, affecting behaviors both related and unrelated to drug seeking and consumption. Using an intracranial self-stimulation reward-based foraging task, we investigated in mice the impact of chronic nicotine on midbrain dopamine neuron activity and its consequence on the trade-off between exploitation and exploration. Model-based and archetypal analysis revealed substantial inter-individual variability in decision-making strategies, with mice passively exposed to nicotine shifting toward a more exploitative profile compared to non-exposed animals. We then mimicked the effect of chronic nicotine on the tonic activity of dopamine neurons using optogenetics, and found that photo-stimulated mice adopted a behavioral phenotype similar to that of mice exposed to chronic nicotine. Our results reveal a key role of tonic midbrain dopamine in the exploration/exploitation trade-off and highlight a potential mechanism by which nicotine affects the exploration/exploitation balance and decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.