ArticleTranslational psychiatry2021
Polygenic risk scores across the extended psychosis spectrum.
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Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
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Who cites it
15 citing papers in PubMed.
- Polygenic profiles in youth with early-onset psychosis and offspring of schizophrenia or bipolar disorder patients.European child & adolescent psychiatry · 2026Article
- Integrating biological pathway polygenic scores and trauma in psychosis: findings from the EU-GEI study.Translational psychiatry · 2026Article
- Genetic Pathways Point to the Biology Underlying the Association Between Cannabis Use Disorder and Psychosis.Biological psychiatry global open science · 2026Article
- Value representation in youth psychopathology: evidence of a transdiagnostic risk mechanism for psychosis.Translational psychiatry · 2026Article
- Associations between psychotic experience dimensions and polygenic liability to schizophrenia in a longitudinal birth cohort.BJPsych open · 2025Article
- Associations of polygenic risk score, environmental factors, and their interactions with the risk of schizophrenia spectrum disorders.Psychological medicine · 2025Article
- Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life.Schizophrenia bulletin · 2025Article
- Genetic Susceptibility to the Environment Moderates the Impact of Childhood Experiences on Psychotic, Depressive, and Anxiety Dimensions.Schizophrenia bulletin · 2025Article
- Schizotypy, Psychosis Proneness, and the Polygenic Risk for Schizophrenia and Resilience.Schizophrenia bulletin · 2025Article
- Association of Polygenic Risk Scores for Schizophrenia with Psychosis-Proneness Indicators in the General Population: A Narrative Review.Consortium psychiatricum · 2025Review
- Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis.Molecular psychiatry · 2024Article
- Epigenomic partitioning of a polygenic risk score for asthma reveals distinct genetically driven disease pathways.The European respiratory journal · 2024Article
- Urbanicity and psychotic disorders: Facts and hypotheses.Dialogues in clinical neuroscience · 2023Review
- Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis.medRxiv : the preprint server for health sciences · 2023Article
- Kalpra: A kernel approach for longitudinal pathway regression analysis integrating network information with an application to the longitudinal PsyCourse Study.Frontiers in genetics · 2022Article
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Authors and funding
60 authors.
Lukasz Smigielski *Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland. lukasz.smigielski@uzh.ch.ORCID http://orcid.org/0000-0002-7428-7644
Sergi Papiol *Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-9366-8728
Anastasia TheodoridouThe Zurich Program for Sustainable Development of Mental Health Services (ZInEP), Psychiatric University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-4792-385X
Karsten HeekerenThe Zurich Program for Sustainable Development of Mental Health Services (ZInEP), Psychiatric University Hospital Zurich, Zurich, Switzerland.
Miriam GerstenbergDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Diana WotrubaThe Zurich Program for Sustainable Development of Mental Health Services (ZInEP), Psychiatric University Hospital Zurich, Zurich, Switzerland.
Roman BuechlerThe Zurich Program for Sustainable Development of Mental Health Services (ZInEP), Psychiatric University Hospital Zurich, Zurich, Switzerland.
Per HoffmannDepartment of Biomedicine, Human Genomics Research Group, University Hospital and University of Basel, Basel, Switzerland.
Stefan HermsDepartment of Biomedicine, Human Genomics Research Group, University Hospital and University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-2786-8200
Kristina AdorjanInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Heike Anderson-SchmidtDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Monika BuddeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-7301-9157
Ashley L ComesInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-6745-9834
Katrin GadeDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Maria HeilbronnerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Urs HeilbronnerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-7135-762X
Janos L KalmanInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-0930-4214
Farahnaz Klöhn-SaghatolislamInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Daniela Reich-ErkelenzInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Sabrina K SchauppInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Eva C SchulteInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Fanny SennerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Ion-George AnghelescuDepartment of Psychiatry and Psychotherapy, Mental Health Institute, Berlin, Germany.
Volker AroltInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Bernhard T BauneDepartment of Psychiatry, University of Münster, Münster, Germany.
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-0623-3759
Detlef E DietrichAMEOS Clinical Center Hildesheim, Hildesheim, Germany.
Andreas J FallgatterDepartment of Psychiatry and Psychotherapy, Tübingen Center for Mental Health (TüCMH), University of Tübingen, Tübingen, Germany.
Christian FiggeKarl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Oldenburg, Germany.
Markus JägerDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
Georg JuckelDepartment of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.
Carsten KonradDepartment of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg, Germany.ORCID http://orcid.org/0000-0001-7015-3860
Vanessa NieratschkerDepartment of Psychiatry and Psychotherapy, Tübingen Center for Mental Health (TüCMH), University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0001-7884-4500
Jens ReimerDepartment of Psychiatry, Klinikum Bremen-Ost, Bremen, Germany.
Eva ReininghausDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.ORCID http://orcid.org/0000-0001-5964-4087
Max SchmaußClinic for Psychiatry, Psychotherapy and Psychosomatics, Augsburg University, Medical Faculty, Bezirkskrankenhaus Augsburg, Augsburg, Germany.
Carsten SpitzerDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Rostock, Germany.
Martin von HagenClinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Eschwege, Germany.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0003-1492-5330
Jörg ZimmermannPsychiatrieverbund Oldenburger Land gGmbH, Karl-Jaspers-Klinik, Bad Zwischenahn, Germany.
Anna GryaznovaInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Laura Flatau-NagelInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Markus ReittDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Milena MeyersDepartment of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.
Barbara EmonsDepartment of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.
Ida Sybille HaußleiterDepartment of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.
Fabian U LangDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
Thomas BeckerDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
Moritz E WigandDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-1571-1468
Franziska DegenhardtInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Andreas J ForstnerInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-1876-6368
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-5236-6149
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Till F M AndlauerDepartment of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-2917-5889
Wulf RösslerThe Zurich Program for Sustainable Development of Mental Health Services (ZInEP), Psychiatric University Hospital Zurich, Zurich, Switzerland.
Susanne WalitzaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Peter Falkai *Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Thomas G Schulze *Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Edna Grünblatt *Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-8505-7265
Funding
No grant is acknowledged in the PubMed record.
Abstract
As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve health outcomes, knowing the probabilistic susceptibility of developing a disorder could guide mitigation measures and clinical intervention. In this context, polygenic risk scores (PRSs) quantifying the additive effects of multiple common genetic variants hold the potential to predict complex diseases and index severity gradients. PRSs for schizophrenia (SZ) and bipolar disorder (BD) were computed using Bayesian regression and continuous shrinkage priors based on the latest SZ and BD genome-wide association studies (Psychiatric Genomics Consortium, third release). Eight well-phenotyped groups (n = 1580; 56% males) were assessed: control (n = 305), lower (n = 117) and higher (n = 113) schizotypy (both groups of healthy individuals), at-risk for psychosis (n = 120), BD type-I (n = 359), BD type-II (n = 96), schizoaffective disorder (n = 86), and SZ groups (n = 384). PRS differences were investigated for binary traits and the quantitative Positive and Negative Syndrome Scale. Both BD-PRS and SZ-PRS significantly differentiated controls from at-risk and clinical groups (Nagelkerke's pseudo-R
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Genome-Wide Association StudyPsychotic DisordersBayes TheoremFemaleGenetic Predisposition to DiseaseHumansMaleMultifactorial InheritanceRisk Factors
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