Evidence map›Paper›PMID 34836924›Full record

ArticleBMJ open respiratory research2021

Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol.

Kensuke Nakagawara, Ho Namkoong, Hideki Terai, Katsunori Masaki, Takae Tanosaki, Kyoko Shimamoto, Ho Lee, Hiromu Tanaka, Satoshi Okamori, Hiroki Kabata and 76 more

Abstract read
In one paragraph

Article in BMJ open respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Japanese nationwide survey to track the impact of long COVID over 3 years.Environmental health and preventive medicine · 2025
    Article
  2. Article
  3. Article
  4. Calcium channel blockers may reduce the development of long COVID in females.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Article
  5. Article
  6. Clinical features of Japanese patients with gastrointestinal long-COVID symptoms.JGH open : an open access journal of gastroenterology and hepatology · 2023
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

86 authors.

Kensuke NakagawaraDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Ho NamkoongDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan hounamugun@gmail.com.
Hideki TeraiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Katsunori MasakiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0003-0909-9409
Takae TanosakiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Kyoko ShimamotoKeio Global Research Institute, Keio University, Tokyo, Japan.
Ho LeeDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Hiromu TanakaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Satoshi OkamoriDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Hiroki KabataDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Shotaro ChubachiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Shinnosuke IkemuraDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Hirofumi KamataDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Hiroyuki YasudaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Ichiro KawadaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Makoto IshiiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Yoshiki IshibashiDepartment of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan.
Sei HaradaDepartment of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan.
Takanori FujitaDepartment of Health Policy and Management, Keio University School of Medicine, Tokyo, Japan.
Daisuke ItoDepartment of Neurology, Keio University School of Medicine, Tokyo, Japan.
Shogyoku BunDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Hajime TabuchiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Sho KanzakiDepartment of Otolaryngology, Keio University School of Medicine, Tokyo, Japan.
Eisuke ShimizuDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Keitaro FukudaDepartment of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Jun YamagamiDepartment of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Keigo KobayashiDepartment of Internal Medicine, Sano Kosei General Hospital, Tochigi, Japan.
Toshiyuki HiranoDepartment of Internal Medicine, Sano Kosei General Hospital, Tochigi, Japan.
Takashi InoueDepartment of Internal Medicine, Sano Kosei General Hospital, Tochigi, Japan.
Junko KagyoDepartment of Internal Medicine, Keiyu Hospital, Kanagawa, Japan.
Tetsuya ShiomiDepartment of Internal Medicine, Keiyu Hospital, Kanagawa, Japan.
Keiko OhginoDivision of Pulmonary Medicine, Kawasaki Municipal Hospital, Kanagawa, Japan.
Koichi SayamaDivision of Pulmonary Medicine, Kawasaki Municipal Hospital, Kanagawa, Japan.
Kengo OtsukaDepartment of Internal Medicine, Nihon Koukan Hospital, Kanagawa, Japan.
Naoki MiyaoDepartment of Internal Medicine, Nihon Koukan Hospital, Kanagawa, Japan.
Toshio OdaniDepartment of Rheumatology, National Hospital Organization Hokkaido Medical Center, Hokkaido, Japan.
Yoshitaka OyamadaDepartment of Respiratory Medicine, National Hospital Organisation Tokyo Medical Center, Tokyo, Japan.
Keita MasuzawaDepartment of Respiratory Medicine, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
Sohei NakayamaDepartment of Respiratory Medicine, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
Yusuke SuzukiDepartment of Respiratory Medicine, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
Rie BabaPulmonary Division, Department Internal Medicine, Saiseikai Utsunomiya Hospital, Tochigi, Japan.
Ichiro NakachiPulmonary Division, Department Internal Medicine, Saiseikai Utsunomiya Hospital, Tochigi, Japan.
Naota KuwaharaDepartment of Medicine, Division of Allergology and Respiratory Medicine, Showa University Koto Toyosu Hospital, Tokyo, Japan.
Takashi IshiguroDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Saitama, Japan.
Shuko MashimoDepartment of Respiratory Medicine, Toyohashi Municipal Hospital, Aichi, Japan.
Naoto MinematsuDepartment of Internal Medicine, Hino Municipal Hospital, Tokyo, Japan.
Soichiro UedaDepartment of Internal Medicine, Saitama Medical Center, Saitama, Japan.
Tadashi ManabeDivision of Pulmonary Medicine, Department of Internal Medicine, Tachikawa Hospital, Tokyo, Japan.
Yohei FunatsuDivision of Pulmonary Medicine, Department of Internal Medicine, Tachikawa Hospital, Tokyo, Japan.
Hidefumi KohDivision of Pulmonary Medicine, Department of Internal Medicine, Tachikawa Hospital, Tokyo, Japan.
Takashi YoshiyamaRespiratory Disease Center, Fukujuji Hospital,Japan Anti-Tuberculosis Association, Tokyo, Japan.
Fumitake SaitoDepartment of Pulmonary Medicine, Eiju General Hospital, Tokyo, Japan.
Kota IshiokaDepartment of Pulmonary Medicine, Saiseikai Central Hospital, Tokyo, Japan.
Saeko TakahashiDepartment of Pulmonary Medicine, Saiseikai Central Hospital, Tokyo, Japan.
Morio NakamuraDepartment of Pulmonary Medicine, Saiseikai Central Hospital, Tokyo, Japan.
Ai GotoDepartment of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
Norihiro HaradaDepartment of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.ORCID 0000-0002-0962-5731
Yu KusakaDepartment of Respiratory Medicine, Ome Municipal General Hospital, Ome, Tokyo, Japan.ORCID 0000-0001-6884-8110
Yasushi NakanoDepartment of Pulmonary Medicine, Kawasaki Municipal Ida Hospital, Kanagawa, Japan.
Kazumi NishioDepartment of Pulmonary Medicine, Kawasaki Municipal Ida Hospital, Kanagawa, Japan.
Hiroki TatenoDepartment of Pulmonary Medicine, Saitama City Hospital, Saitama, Japan.
Ryuya EdahiroDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
Yoshito TakedaDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
Atsushi KumanogohDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
Nobuhiro KodamaDepartment of General Internal Medicine, Fukuoka Tokushukai Hospitali, Fukuoka, Japan.
Masaki OkamotoDepartment of Internal Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Fukuoka, Japan.
Akira UmedaDepartment of Respiratory Medicine, International University of Health and Welfare Shioya Hospital, Tochigi, Japan.
Kazuto HagimuraClinical and Translational Research Center, Keio University Hospital, Tokyo, Japan.
Toshiro SatoDepartment of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.
Naoki MiyazakiBiostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo, Japan.
Ryo TakemuraBiostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo, Japan.
Yasunori SatoBiostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo, Japan.
Toru TakebayashiDepartment of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan.
Jin NakaharaDepartment of Neurology, Keio University School of Medicine, Tokyo, Japan.
Masaru MimuraDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Kaoru OgawaDepartment of Otolaryngology, Keio University School of Medicine, Tokyo, Japan.
Shigeto ShimmuraDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Kazuno NegishiDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Kazuo TsubotaDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Masayuki AmagaiDepartment of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Rei GotoGraduate School of Business Administration, Keio University, Tokyo, Japan.
Yoko IbukaFaculty of Economics, Keio University, Tokyo, Japan.
Naoki HasegawaDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Yuko KitagawaDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Takanori KanaiDivision of Gastroenterology and Hepatology Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Koichi FukunagaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe rapid spread of COVID-19 posed a global burden. Substantial number of people died of the disease in the acute phase of infection. In addition, a significant proportion of patients have been reported to suffer from post-acute phase symptoms, sequelae of COVID-19, which may negatively influence the quality of daily living and/or socioeconomic circumstances of the patients. However, no previous study has comprehensively and objectively assessed the quality of life of patients by using existing international scales. Further, evidence of socioeconomic consequences among patients with COVID-19 is scarce. To address the multidimensional issues from sequelae of COVID-19, evidence from comprehensive surveys beyond clinical perspectives is critical that investigates health, and social determinants of disease progression as well as socioeconomic consequences at a large scale. METHODS AND ANALYSIS: In this study, we plan to conduct a nationwide and comprehensive survey for the sequelae of COVID-19 in a total of 1000 patients diagnosed at 27 hospitals throughout Japan. This study will evaluate not only the health-related status of patients from clinical perspectives but also the Health-related Quality of Life (HRQoL) scores, socioeconomic status and consequences to discuss the sequelae of the disease and the related risk factors. The primary endpoint is the frequency of long-term complications of COVID-19 infection. The secondary endpoints are risk factors for progression to sequelae of COVID-19 infection. The study will provide robust and important evidence as a resource to tackle the issues from the sequelae of COVID-19 from the multi-dimensional perspectives. ETHICS AND DISSEMINATION: This trial was approved by the Keio University School of Medicine Ethics Committee (20200243, UMIN000042299). The results of this study will be reported at a society meeting or published in a peer-reviewed journal.

Indexed as

COVID-19Cohort StudiesDisease ProgressionHumansJapanMulticenter Studies as TopicQuality of LifeSARS-CoV-2clinical epidemiologyCOVID-19respiratory infection

Identifiers

PMID34836924
PMCPMC8628335

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