Evidence map›Paper›PMID 34836911›Full record

ArticleBMJ global health2021

Antibiotic stories: a mixed-methods, multi-country analysis of household antibiotic use in Malawi, Uganda and Zimbabwe.

Justin Dixon, Eleanor Elizabeth MacPherson, Susan Nayiga, Salome Manyau, Christine Nabirye, Miriam Kayendeke, Esnart Sanudi, Alex Nkaombe, Portia Mareke, Kenny Sitole and 10 more

Open access · goldAbstract read
In one paragraph

Article in BMJ global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 4 countries.

Justin DixonDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK Justin.Dixon@lshtm.ac.uk.ORCID 0000-0002-7706-7305
Eleanor Elizabeth MacPhersonMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.ORCID 0000-0002-7142-1158
Susan NayigaDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-1895-4035
Salome ManyauDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-0452-5475
Christine NabiryeInfectious Diseases Research Collaboration, Kampala, Uganda.ORCID 0000-0002-7724-9635
Miriam KayendekeInfectious Diseases Research Collaboration, Kampala, Uganda.ORCID 0000-0003-1881-3774
Esnart SanudiMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.ORCID 0000-0002-8830-6260
Alex NkaombeMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Portia MarekeBiomedical Research and Training Institute, Harare, Zimbabwe.ORCID 0000-0003-4412-0613
Kenny SitoleBiomedical Research and Training Institute, Harare, Zimbabwe.
Coll de Lima HutchisonDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-0065-6507
John BradleyDepartment of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Shunmay YeungDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-0997-0850
Rashida Abbas FerrandBiomedical Research and Training Institute, Harare, Zimbabwe.ORCID 0000-0002-7660-9176
Sham LalDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-3650-1398
Chrissy RobertsDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0003-1064-5980
Edward GreenMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.ORCID 0000-0002-2440-4355
Laurie Denyer WillisSchool of Social and Political Science, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-2630-9092
Sarah G StaedkeInfectious Diseases Research Collaboration, Kampala, Uganda.ORCID 0000-0003-2505-821X
Clare I R ChandlerDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0001-6499-7522
London School of Hygiene & Tropical Medicine · GBUniversity of Liverpool · GBBiomedical Research and Training Institute · ZWInfectious Diseases Research Collaboration · UGUniversity of Edinburgh · GB

Funding

Medical Research Council MR/R010161/1Medical Research Council MR/S004793/1Wellcome Trust 206316/Z/17/Z
6 · The paper itself

Abstract

backgroundAs concerns about the prevalence of infections that are resistant to available antibiotics increase, attention has turned toward the use of these medicines both within and outside of formal healthcare settings. Much of what is known about use beyond formal settings is informed by survey-based research. Few studies to date have used comparative, mixed-methods approaches to render visible patterns of use within and between settings as well as wider points of context shaping these patterns.

designThis article analyses findings from mixed-methods anthropological studies of antibiotic use in a range of rural and urban settings in Zimbabwe, Malawi and Uganda between 2018 and 2020. All used a 'drug bag' survey tool to capture the frequency and types of antibiotics used among 1811 households. We then undertook observations and interviews in residential settings, with health providers and key stakeholders to better understand the stories behind the most-used antibiotics.

resultsThe most self-reported 'frequently used' antibiotics across settings were amoxicillin, cotrimoxazole and metronidazole. The stories behind their use varied between settings, reflecting differences in the configuration of health systems and antibiotic supplies. At the same time, these stories reveal cross-cutting features and omissions of contemporary global health programming that shape the contours of antibiotic (over)use at national and local levels.

conclusionsOur findings challenge the predominant focus of stewardship frameworks on the practices of antibiotic end users. We suggest future interventions could consider systems-rather than individuals-as stewards of antibiotics, reducing the need to rely on these medicines to fix other issues of inequity, productivity and security.

Indexed as

Anti-Bacterial AgentsRural PopulationHumansMalawiUgandaZimbabweAnti-Bacterial Agentspublic healthqualitative study

Identifiers

PMID34836911
PMCPMC8628329
OpenAlexW3217200218

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.