Evidence map›Paper›PMID 34836627›Full record

ArticleComputers in biology and medicine2022

Native-resolution myocardial principal Eulerian strain mapping using convolutional neural networks and Tagged Magnetic Resonance Imaging.

Inas A Yassine, Ahmed M Ghanem, Nader S Metwalli, Ahmed Hamimi, Ronald Ouwerkerk, Jatin R Matta, Michael A Solomon, Jason M Elinoff, Ahmed M Gharib, Khaled Z Abd-Elmoniem

Abstract read
In one paragraph

Article in Computers in biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Inas A YassineSystems and Biomedical Engineering Department, Faculty of Engineering, Cairo University, Egypt.
Ahmed M GhanemBiomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Nader S MetwalliBiomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Ahmed HamimiBiomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Ronald OuwerkerkBiomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Jatin R MattaBiomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Michael A SolomonCardiovascular Branch of the National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA; Critical Care Medicine Department, NIH Clinical Center, Bethesda, MD, USA.
Jason M ElinoffCritical Care Medicine Department, NIH Clinical Center, Bethesda, MD, USA.
Ahmed M GharibBiomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Khaled Z Abd-ElmoniemBiomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA. Electronic address: abdelmoniemkz@mail.nih.gov.

Funding

Advanced Non Invasive Vascular Imaging MethodsZIADK075083 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GHARIB, AHMED · 2013 to 2025
$34.7M
Isolation/Characterization CECs Pulmonary ArteriopathyZ01CL008069 · CLC · CLINICAL CENTER · PI SOLOMON, MICHAEL A · 2004 to 2008
$95k
Endothelial Cell Dysfunction in Pulmonary Arterial HypertensionZIACL008069 · CLC · CLINICAL CENTER · PI SOLOMON, MICHAEL · 2009 to 2019
$0k
A Phase 1 Clinical Trial of ABI-009, an mTOR Inhibitor, for Patients with Severe Pulmonary Arterial Hypertension (PAH)ZIACL009026 · CLC · CLINICAL CENTER · PI ELINOFF, JASON MATTHEW · 2018 to 2022
$0k
Development of a Pre-Clinical Rodent Model of Pulmonary Arterial HypertensionZIACL090059 · CLC · CLINICAL CENTER · PI ELINOFF, JASON MATTHEW · 2019 to 2022
$0k
Clinical Translational Research Program in Pulmonary Arterial Hypertension (PAH): Disease Mechanisms, Biomarkers, and Novel Therapeutic TargetsZIACL090066 · CLC · CLINICAL CENTER · PI SOLOMON, MICHAEL · 2020 to 2025
$0k
Intramural NIH HHS Z01 CL008069Intramural NIH HHS Z99 DK999999Intramural NIH HHS ZIA CL008069Intramural NIH HHS ZIA CL009026Intramural NIH HHS ZIA CL090059Intramural NIH HHS ZIA DK075083
6 · The paper itself

Abstract

backgroundAssessment of regional myocardial function at native pixel-level resolution can play a crucial role in recognizing the early signs of the decline in regional myocardial function. Extensive data processing in existing techniques limits the effective resolution and accuracy of the generated strain maps. The purpose of this study is to compute myocardial principal strain maps ε

methodsFor network training, validation, and testing, realistic tMRI datasets were generated and consisted of 53,606 cine images simulating the heart, the liver, blood pool, and backgrounds, including ranges of shapes, positions, motion patterns, noise, and strain. In addition, 102 in-vivo image datasets from three healthy subjects, and three Pulmonary Arterial Hypertension patients, were acquired and used to assess the network's in-vivo performance. Four convolutional neural networks were trained for mapping input tagging patterns to corresponding ground-truth principal strains using different cost functions. Strain maps using harmonic phase analysis (HARP) were obtained with various spectral filtering settings for comparison. CNN and HARP strain maps were compared at the pixel level versus the ground-truth and versus the least-loss in-vivo maps using Pearson correlation coefficients (R) and the median error and Inter-Quartile Range (IQR) histograms.

resultsCNN-based local patch DeepStrain maps at a phantom resolution of 1.1mm × 1.1 mm and in-vivo resolution of 2.1mm × 1.6 mm were artifact-free with multiple fold improvement with ε

conclusionCNN-generated Eulerian strain mapping permits artifact-free visualization of myocardial function at the native image resolution.

Indexed as

Magnetic Resonance ImagingNeural Networks, ComputerHeartHumansImage Processing, Computer-AssistedMyocardiumPhantoms, ImagingConvolutional neural networkDeep learningDeepStrainHarmonic phaseMyocardial strain mappingTagging MRI

Identifiers

PMID34836627
PMCPMC8900530

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.