ArticleBMC ophthalmology2021
High myopia and macular vascular density: an optical coherence tomography angiography study.
Article in BMC ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Molecular and Biomechanical Changes in the Anterior Segment of High Myopic Eyes.Annals of biomedical engineering · 2026Review
- Alterations in Macular and Peripapillary Vessel Density Following Implantable Collamer Lens Surgery in Highly Myopic Eyes and Their Potential Association with 2-Year Axial Length Changes.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- The Significance of OCTA in Studying Vessel Density and Retinal Thickness in Individuals with Myopia.Medicina (Kaunas, Lithuania) · 2025Article
- Differences in macular structure and microvasculature between high myopia and non-high myopia.Frontiers in medicine · 2025Article
- Hemoglobin oxygen saturation in myopic eyes: a scanning laser ophthalmoscope study.International journal of ophthalmology · 2025Article
- Investigation of choroidal vascular alterations in eyes with myopia using ultrawidefield optical coherence tomography angiography.BMJ open ophthalmology · 2024Article
- Clinical outcomes of posterior scleral reinforcement in Chinese high myopia children.Scientific reports · 2024Article
- IMI-Nonpathological Human Ocular Tissue Changes With Axial Myopia.Investigative ophthalmology & visual science · 2023Article
- The Influence of Myopia on the Foveal Avascular Zone and Density of Blood Vessels of the Macula-An OCTA Study.Medicina (Kaunas, Lithuania) · 2023Article
- Comparison of Retinal Microvascular Vascular Density Between Adolescents With and Without Simple Myopia Using Optical Coherence Tomography Angiography.The Eurasian journal of medicine · 2023Article
- Editorial: Functional assessments of the ocular circulation.Frontiers in medicine · 2023Article
- Choroidal Vascular Density Quantification in High Myopia with or without Choroidal Neovascularization Using Optical Coherence Tomography Angiography.Journal of ophthalmology · 2023Article
- Prospective clinical study of retinal microvascular alteration after ICL implantation.Frontiers in cell and developmental biology · 2023Article
- The correlation between modifications to corneal topography and changes in retinal vascular density and retinal thickness in myopic children after undergoing orthokeratology.Frontiers in medicine · 2023Article
- Different approaches for treating myopic choroidal neovascularization: a network Meta-analysis.International journal of ophthalmology · 2023Article
- Ultra-Widefield Swept-Source Optical Coherence Tomography Angiography in the Assessment of Choroidal Changes in Young Adults With Myopia.Translational vision science & technology · 2022Article
- Peripapillary vessel density correlates with visual field mean sensitivity in highly myopic eyes.Journal of translational medicine · 2022Article
- The optical coherence tomography angiography study on paediatric COVID-19 cases.Photodiagnosis and photodynamic therapy · 2022Article
- Advanced ultrawide-field optical coherence tomography angiography identifies previously undetectable changes in biomechanics-related parameters in nonpathological myopic fundus.Frontiers in bioengineering and biotechnology · 2022Article
- Assessment of macular structures and vascular characteristics in highly myopic anisometropia using swept-source optical coherence tomography angiography.Frontiers in physiology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether there are differences inmacular vascular density (VD) between patients with high-myopia (HM) and those with non-high myopia (NHM) using Optical Coherence Tomography Angiography (OCTA).
methodOCTA was performed on 35 eyes with HM with spherical equivalence (SE) > - 6.00D and 35 eyes with NHM with SE ≤ -6.00D. Vascular densities of the macula (overall macula, fovea, parafovea, superior hemi and inferior hemi) were measured in each of the superficial, deep and choriocapillaris layers of the retina.
resultsIn the superficial retinal layer, overall macular VFD was significantly higher in the NHM compared to the HM group (51.27 ± 3.74 vs. 48.07 ± 5.69, p < 0.05). There were significant differences between the NHM and HM in parafovea (52.58 ± 5.78 vs. 49.4 ± 6.43, p < 0.05), superior-hemi (53.38 ± 4.03 vs 49.78 ± 6.84, p < 0.05) and inferior-hemi regions (53.49 ± 4.61 vs 49.05 ± 6.41, p < 0.05), but not in the fovea region. Similarly, in the deep retinal layer, overall macular VFD was significantly higher in the NHM group compared to the HM group (58.69 ± 2.46 vs. 56.90 ± 4.08, p < 0.05). There was significant differences between the HM and NHM in superior-hemi region (61.97 ± 2.68 vs. 60.08 ± 3.98, p < 0.05), but not in the fovea, parafovea, and inferior-hemi region. In the choriocapillaris, there was no difference in the overall macular VFD, nor any of the individual sectors between the HM and the NHM groups.
conclusionVFD in the superficial and deep retinal layers of the macula are significantly increased in the NHM compared to HM eyes. This is not the case in the choroidal capillary layers of the retina.
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