Evidence map›Paper›PMID 34836431›Full record

ReviewNutrients2021

Obesity and Cardiometabolic Risk Factors: From Childhood to Adulthood.

Dorota Drozdz, Julio Alvarez-Pitti, Małgorzata Wójcik, Claudio Borghi, Rosita Gabbianelli, Artur Mazur, Vesna Herceg-Čavrak, Beatriz Gonzalez Lopez-Valcarcel, Michał Brzeziński, Empar Lurbe and 1 more

Abstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 227 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
227citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

227 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  13. Gender diversity and cholesterol in early adolescence: Findings from the Adolescent Brain Cognitive Development Study.International journal of cardiology. Cardiovascular risk and prevention · 2026
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  20. Testing theChildhood obesity (Print) · 2026
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167 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dorota DrozdzDepartment of Pediatric Nephrology and Hypertension, Pediatric Institute, Jagiellonian University Medical College, 30-663 Cracow, Poland.ORCID 0000-0002-1281-1164
Julio Alvarez-PittiPediatric Department, Consorcio Hospital General, University of Valencia, 46014 Valencia, Spain.ORCID 0000-0003-0452-7822
Małgorzata WójcikDepartment of Pediatric and Adolescent Endocrinology, Pediatric Institute, Jagiellonian University Medical College, 30-663 Cracow, Poland.ORCID 0000-0003-3889-1913
Claudio BorghiDepartment of Medical and Surgical Sciences, University of Bologna-IRCCS S. Orsola, 40126 Bologna, Italy.ORCID 0000-0001-8039-8781
Rosita GabbianelliUnit of Molecular Biology and Nutrigenomics, School of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0003-0037-7740
Artur MazurDepartment of Pediatrics, Pediatric Endocrinology and Diabetes, Medical Faculty, University of Rzeszów, 35-310 Rzeszów, Poland.ORCID 0000-0001-5393-3515
Vesna Herceg-ČavrakChildren's Hospital Zagreb, Libertas International University, 10000 Zagreb, Croatia.ORCID 0000-0002-1723-1791
Beatriz Gonzalez Lopez-ValcarcelDepartment of Quantitative Methods for Economics and Management, University of Las Palmas de Gran Canaria; 35017 Las Palmas, Spain.
Michał BrzezińskiDepartment of Pediatrics, Gastroenterology, Allergology and Pediatric Nutrition, Medical University of Gdansk, 80-210 Gdansk, Poland.ORCID 0000-0002-3426-507X
Empar LurbePediatric Department, Consorcio Hospital General, University of Valencia, 46014 Valencia, Spain.ORCID 0000-0002-3748-5529
Elke WühlDivision of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0002-1205-2620

Funding

European Union CA19115 HyperChildNET
6 · The paper itself

Abstract

Obesity has become a major epidemic in the 21st century. It increases the risk of dyslipidemia, hypertension, and type 2 diabetes, which are known cardiometabolic risk factors and components of the metabolic syndrome. Although overt cardiovascular (CV) diseases such as stroke or myocardial infarction are the domain of adulthood, it is evident that the CV continuum begins very early in life. Recognition of risk factors and early stages of CV damage, at a time when these processes are still reversible, and the development of prevention strategies are major pillars in reducing CV morbidity and mortality in the general population. In this review, we will discuss the role of well-known but also novel risk factors linking obesity and increased CV risk from prenatal age to adulthood, including the role of perinatal factors, diet, nutrigenomics, and nutri-epigenetics, hyperuricemia, dyslipidemia, hypertension, and cardiorespiratory fitness. The importance of 'tracking' of these risk factors on adult CV health is highlighted and the economic impact of childhood obesity as well as preventive strategies are discussed.

Indexed as

Cardiometabolic Risk FactorsAdolescentAdultCardiorespiratory FitnessCardiovascular DiseasesChildChild, PreschoolDietEpigenomicsFemaleHumansInfantInfant, NewbornMaleMetabolic SyndromeNutrigenomicscardiometabolic risk factorsdyslipidemiahypertensionnutrigenomicsobesitytracking phenomenon

Identifiers

PMID34836431
PMCPMC8624977

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.