Evidence map›Paper›PMID 34836412›Full record

ArticleNutrients2021

Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.

Enrique Almanza-Aguilera, Daniela Ceballos-Sánchez, David Achaintre, Joseph A Rothwell, Nasser Laouali, Gianluca Severi, Verena Katzke, Theron Johnson, Matthias B Schulze, Domenico Palli and 6 more

Abstract readMulticenter Study
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Enrique Almanza-AguileraUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.ORCID 0000-0002-4805-0774
Daniela Ceballos-SánchezUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.
David AchaintreNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France.ORCID 0000-0002-5566-3130
Joseph A RothwellUVSQ, Inserm, CESP U1018, "Exposome and Heredity" Team, Université Paris-Saclay, Gustave Roussy, 94800 Villejuif, France.
Nasser LaoualiUVSQ, Inserm, CESP U1018, "Exposome and Heredity" Team, Université Paris-Saclay, Gustave Roussy, 94800 Villejuif, France.ORCID 0000-0002-8532-456X
Gianluca SeveriUVSQ, Inserm, CESP U1018, "Exposome and Heredity" Team, Université Paris-Saclay, Gustave Roussy, 94800 Villejuif, France.
Verena KatzkeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Theron JohnsonDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), 50139 Florence, Italy.ORCID 0000-0002-5558-2437
Giuliana GarganoEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.ORCID 0000-0002-0813-3022
Maria Santucci de MagistrisDipartimento di Medicina Clinica e Chirurgia, Federico II University, 80131 Naples, Italy.
Rosario TuminoCancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), 97100 Ragusa, Italy.
Carlotta SacerdoteUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, 10126 Turin, Italy.
Augustin ScalbertNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France.ORCID 0000-0001-6651-6710
Raul Zamora-RosUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.ORCID 0000-0002-6236-6804

Funding

World Health Organization 001
6 · The paper itself

Abstract

This study examines the correlation of acute and habitual dietary intake of flavan-3-ol monomers, proanthocyanidins, theaflavins, and their main food sources with the urinary concentrations of (+)-catechin and (-)-epicatechin in the European Prospective Investigation into Cancer and Nutrition study (EPIC). Participants (N = 419, men and women) provided 24-h urine samples and completed a 24-h dietary recall (24-HDR) on the same day. Acute and habitual dietary data were collected using a standardized 24-HDR software and a validated dietary questionnaire, respectively. Intake of flavan-3-ols was estimated using the Phenol-Explorer database. Concentrations of (+)-catechin and (-)-epicatechin in 24-h urine were analyzed using tandem mass spectrometry after enzymatic deconjugation. Simple and partial Spearman's correlations showed that urinary concentrations of (+)-catechin, (-)-epicatechin and their sum were more strongly correlated with acute than with habitual intake of individual and total monomers (acute

Indexed as

AdultAgedBiflavonoidsBiomarkersCatechinDietDiet SurveysEatingEuropeFemaleFlavonoidsHumansMaleMiddle AgedNutrition AssessmentProanthocyanidinsBiflavonoidsBiomarkersCatechinflavan-3-olFlavonoidsProanthocyanidinstheaflavinbiomarkerscatechinEPICepicatechinflavan-3-olsintakeurine

Identifiers

PMID34836412
PMCPMC8624971

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.