ReviewNutrients2021
Role of Citrus Fruit Juices in Prevention of Kidney Stone Disease (KSD): A Narrative Review.
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Lime-based supplement reduces calcium oxalate stone recurrence: A multicenter randomized controlled trial.PloS one · 2025Trial
- Metabolic evaluation of urolithiasis: a narrative review.Urologie (Heidelberg, Germany) · 2025Review
- Balancing Stone Prevention and Kidney Function: A Therapeutic Dilemma.Journal of clinical medicine · 2025Review
- Both absolute and relative sugar-sweetened beverage intake are associated with kidney stones in U.S. middle-aged and young adults.World journal of urology · 2025Article
- Urinary health indicators in folivorous-frugivorous primates with and without food supplementation.Primates; journal of primatology · 2025Article
- Associations between comprehensive dietary composition and kidney stone risk: insights from a nationally representative survey.Frontiers in nutrition · 2025Article
- Higher dietary insulin index is directly associated with the odd of kidney stones.Scientific reports · 2024Article
- Impact of diet on renal stone formation.Journal of family medicine and primary care · 2024Review
- The Multidisciplinary Approach in the Management of Patients with Kidney Stone Disease-A State-of-the-Art Review.Nutrients · 2024Review
- Kidney stones and dietary intake in adults: a population-based study in southwest Iran.BMC public health · 2024Article
- Kidney stones: natural remedies and lifestyle modifications to alleviate their burden.International urology and nephrology · 2024Review
- Investigation of the application of Enhanced Recovery After Surgery (ERAS) in elderly patients undergoing surgery for kidney stones.American journal of translational research · 2024Article
- Current Dietary and Medical Prevention of Renal Calcium Oxalate Stones.International journal of general medicine · 2024Review
- Unlocking New Approaches to Urolithiasis ManagementCurrent pharmaceutical biotechnology · 2024Review
- Effects of lemon-tomato juice consumption on crystal formation in the urine of patients with calcium oxalate stones: A randomized crossover clinical trial.Current urology · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To explore the relationship between citrus fruit juices (oranges, grapefruits, and lemonades) and kidney stone disease (KSD).
methodsA systematic review was performed using the Medline, EMBASE, and Scopus databases, in concordance with the PRISMA checklist for all English, French, and Spanish language studies regarding the consumption of citrus fruit juices and the relationship to urinary stone disease. The main outcome of interest was the association of citrus fruit juices with KSD.
resultsThirteen articles met the criteria for inclusion in the final review. Three large epidemiological studies found that grapefruit juice was a risk factor for stone formation, while orange juice did not increase the risk for KSD. Ten small prospective clinical studies found that orange, grapefruit, and lemon juices all increased urinary citrate levels. Only orange and grapefruit juices had an alkalinizing effect and while lemon juice has a protective effect by raising urinary citrate levels, it lacked a significant alkalinizing effect on urine pH. Orange juice and grapefruit juices significantly increased urinary oxalate levels, while orange juice also had a high carbohydrate content.
conclusionWhile orange juice seems to play a protective role against stone formation, grapefruit was found to raise the risk of KSD in epidemiological studies but had a protective role in smaller clinical studies. Lemon juice had a smaller protective role than orange juice. Larger amounts of, as well as more accurate, data is needed before recommendations can be made and a high carbohydrate content in these juices needs to be taken into consideration.
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