ReviewNutrients2021
Protein Appetite at the Interface between Nutrient Sensing and Physiological Homeostasis.
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Macronutrient mixtures and interactions in health and disease.Nature reviews. Endocrinology · 2026Review
- Two neuropeptides that promote blood feeding ineLife · 2026Article
- FGF21 signals through hindbrain neurons to alter food intake and energy expenditure during dietary protein restriction.Cell reports · 2026Article
- Impact of Varied Dietary Macronutrient Ratios on the Nutrition Status of Swiss Albino Mice.Food science & nutrition · 2025Article
- Targeted cravings: Unraveling the drivers of nutrient-specific appetite.Current opinion in neurobiology · 2025Review
- Dietary macronutrient content and energy intake in the mouse: hedonic or homeostatic override?Obesity (Silver Spring, Md.) · 2025Article
- Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan.Nature metabolism · 2025Article
- Amino acids activate parallel chemosensory pathways in Drosophila.Chemical senses · 2025Article
- A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster.Nature communications · 2024Article
- FGF21 as a mediator of adaptive changes in food intake and macronutrient preference in response to protein restriction.Neuropharmacology · 2024Review
- FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling.bioRxiv : the preprint server for biology · 2024Article
- Article
- Protein appetite as an integrator in the obesity system: the protein leverage hypothesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Supplementation with protected kapok seed oil and choline chloride to improve the performance and lipid status of thin-tailed sheep.Veterinary world · 2023Article
- Testing for Protein Leverage in Patients with Gastric Bypass: A Pilot Study.Annals of nutrition & metabolism · 2023Article
- Macronutrient intake: Hormonal controls, pathological states, and methodological considerations.Appetite · 2023Review
- Resource allocation in mammalian systems.Biotechnology advancesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Feeding behavior is guided by multiple competing physiological needs, as animals must sense their internal nutritional state and then identify and consume foods that meet nutritional needs. Dietary protein intake is necessary to provide essential amino acids and represents a specific, distinct nutritional need. Consistent with this importance, there is a relatively strong body of literature indicating that protein intake is defended, such that animals sense the restriction of protein and adaptively alter feeding behavior to increase protein intake. Here, we argue that this matching of food consumption with physiological need requires at least two concurrent mechanisms: the first being the detection of internal nutritional need (a protein need state) and the second being the discrimination between foods with differing nutritional compositions. In this review, we outline various mechanisms that could mediate the sensing of need state and the discrimination between protein-rich and protein-poor foods. Finally, we briefly describe how the interaction of these mechanisms might allow an animal to self-select between a complex array of foods to meet nutritional needs and adaptively respond to changes in either the external environment or internal physiological state.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.