Evidence map›Paper›PMID 34836323›Full record

ArticleNutrients2021

Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study.

Cheng Chi, Yali Fan, Cheng Li, Yu Li, Shan Guo, Tianhe Li, Nicholas Buys, Vicki L Clifton, Paul B Colditz, Chenghong Yin and 1 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Impact of mother's own milkMicrobiome research reports · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Determinants of microbial colonization in the premature gut.Molecular medicine (Cambridge, Mass.) · 2023
    Review
  10. Review
  11. Feed Safety and the Development of Poultry Intestinal Microbiota.Animals : an open access journal from MDPI · 2022
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Cheng ChiBeijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Yali FanBeijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Cheng LiSchool of Nursing, Jining Medical University, Jining 272067, China.
Yu LiSchool of Nursing, Weifang Medical University, Weifang 261042, China.
Shan GuoBeijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Tianhe LiBeijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Nicholas BuysMenzies Health Institute Queensland, School of Medicine and Dentistry, Griffith University, Gold Coast, QLD 4215, Australia.
Vicki L CliftonFaculty of Medicine, Mater Research Institute, Translational Research Institute, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-4892-6748
Paul B ColditzPerinatal Research Centre, UQCCR, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.
Chenghong YinBeijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Jing SunMenzies Health Institute Queensland, School of Medicine and Dentistry, Griffith University, Gold Coast, QLD 4215, Australia.ORCID 0000-0002-0097-2438
Capital Medical University · CNGriffith University · AUJining Medical University · CNThe University of Queensland · AUTranslational Research Institute · AUWeifang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Premature infants have a fragile ecology of the gut microbiota, which is associated with many health problems and may be influenced by formula versus breast feeding. The present study investigated differences in the process of gut microbiota colonisation in preterm infants fed with breastmilk or formula with or without probiotics before 12 weeks. This cohort study recruited 138 premature infants; 31 in the breastmilk (BM) group, 59 in the probiotics formula (PF) group and 48 in the non-probiotics formula (NPF) group, according to the feeding practice they received at birth. Gut bacterial composition was identified with 16S rRNA gene sequencing in faecal samples collected at 1 week, 6 weeks and 12 weeks after birth. The alpha diversity was higher in the PF group compared to the other groups at week 1 and 6 (both

Indexed as

Infant FormulaInfant, PrematureMilk, HumanBifidobacteriumEnterococcusFecesFemaleGastrointestinal MicrobiomeHumansInfant, NewbornInfant Nutritional Physiological PhenomenaMaleProbioticsRNA, Ribosomal, 16SStreptococcusRNA, Ribosomal, 16Smicrobiotapreterm infantsprobiotics

Identifiers

PMID34836323
PMCPMC8624512
OpenAlexW3213847395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.