ArticleNutrients2021
Early-Life Exposure to Famine and Risk of Metabolic Associated Fatty Liver Disease in Chinese Adults.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 17 citations in OpenAlex.
- Impact of Early Life Famine Exposure on Body Composition and Metabolic Profiles in Adulthood.Maternal & child nutrition · 2025Article
- Association between fetal exposure to the Chinese famine and cognitive decline in adulthood: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Great leap forward famine exposure and urban-rural migration convolute the modern prevalence of diabetes in China.Journal of health, population, and nutrition · 2024Article
- Exposure to famine during early life and the risk of MAFLD during adulthood: evidence from the China Multi-Ethnic Cohort (CMEC) study.BMJ public health · 2024Article
- Genetic Ablation of C/EBPα-p300 Pathway Blocks Development of Obese Pregnancy Associated Liver Disorders in Offspring.Cellular and molecular gastroenterology and hepatology · 2024Article
- Famine exposure in early life increases risk of cataracts in elderly stage.Frontiers in nutrition · 2024Article
- Maternal obesity induced metabolic disorders in offspring and myeloid reprogramming by epigenetic regulation.Frontiers in endocrinology · 2023Review
- Review
- Prenatal ozone exposure programs a sexually dimorphic susceptibility to high-fat diet in adolescent Long Evans rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Early life programming of health and disease: The long-term consequences of obesity in pregnancy.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022Review
- Association Between NLR and NAFLD in Adults Exposed to Famine in Early Life.Risk management and healthcare policy · 2022Article
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7 authors at 2 institutions in 1 country.
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Abstract
backgroundEarly-life exposure to the Chinese famine has been related to the risk of obesity, type 2 diabetes, and nonalcoholic fatty liver disease later in life. Nevertheless, the long-term impact of famine exposure on metabolic associated fatty liver disease (MAFLD), a recently proposed term to describe liver disease associated with known metabolic dysfunction, remains unknown. The aim of our study was to explore the relationship between early famine exposure and MAFLD in adulthood.
methodsA total of 26,821 participants (10,994 men, 15,827 women) were recruited from a cohort study of Chinese adults in Shanghai. We categorized participants into four famine exposure subgroups based on the birth year as nonexposed (1963-1967), fetal-exposed (1959-1962), childhood-exposed (1949-1958), and adolescence-exposed (1941-1948). MAFLD was defined as liver steatosis detected by ultrasound plus one of the following three criteria: overweight/obesity, type 2 diabetes, or evidence of metabolic dysregulation. Multivariable logistic regression models were performed to examine the association between famine exposure and MAFLD.
resultsThe mean ± standard deviation age of the participants was 60.8 ± 6.8 years. The age-adjusted prevalence of MAFLD was 38.3, 40.8, 40.1, and 36.5% for the nonexposed, fetal-exposed, childhood-exposed, and adolescence-exposed subgroups, respectively. Compared with nonexposed participants, fetal-exposed participants showed an increased risk of adulthood MAFLD (OR = 1.10, 95% CI 1.00-1.21). The significant association between fetal famine exposure and MAFLD was observed in women (OR = 1.22, 95% CI 1.08-1.37), but not in men (OR = 0.88, 95% CI 0.75-1.03). In age-balanced analyses combining pre-famine and post-famine births as the reference, women exposed to famine in the fetal stage still had an increased risk of MAFLD (OR = 1.15, 95% CI 1.05-1.26).
conclusionsPrenatal exposure to famine showed a sex-specific association with the risk of MAFLD in adulthood.
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