Evidence map›Paper›PMID 34836313›Full record

ReviewNutrients2021

Potential Nutrients from Natural and Synthetic Sources Targeting Inflammaging-A Review of Literature, Clinical Data and Patents.

Sushruta Koppula, Mahbuba Akther, Md Ezazul Haque, Spandana Rajendra Kopalli

Abstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Impact of Dietary Fiber on Inflammation in Humans.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sushruta KoppulaDepartment of Integrated Biosciences, College of Biomedical & Health Science, Konkuk University, Chungju 27381, Korea.ORCID 0000-0002-8597-7763
Mahbuba AktherDepartment of Integrated Biosciences, College of Biomedical & Health Science, Konkuk University, Chungju 27381, Korea.
Md Ezazul HaqueDepartment of Applied Life Science, Graduate School, BK21 Program, Konkuk University, Chungju 27381, Korea.ORCID 0000-0002-5625-3547
Spandana Rajendra KopalliDepartment of Bioscience and Biotechnology, Sejong University, Gwangjin-gu, Seoul 05006, Korea.ORCID 0000-0002-3379-4797

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammaging, the steady development of the inflammatory state over age is an attributable characteristic of aging that potentiates the initiation of pathogenesis in many age-related disorders (ARDs) including neurodegenerative diseases, arthritis, cancer, atherosclerosis, type 2 diabetes, and osteoporosis. Inflammaging is characterized by subclinical chronic, low grade, steady inflammatory states and is considered a crucial underlying cause behind the high mortality and morbidity rate associated with ARDs. Although a coherent set of studies detailed the underlying pathomechanisms of inflammaging, the potential benefits from non-toxic nutrients from natural and synthetic sources in modulating or delaying inflammaging processes was not discussed. In this review, the available literature and recent updates of natural and synthetic nutrients that help in controlling inflammaging process was explored. Also, we discussed the clinical trial reports and patent claims on potential nutrients demonstrating therapeutic benefits in controlling inflammaging and inflammation-associated ARDs.

Indexed as

AgingDietary SupplementsNutrientsHumansImmunosenescenceInflammationPatents as TopicNutrientsaging related disordersinflammaginglow grade inflammationnatural herbsnutrientspro-inflammatory cytokines

Identifiers

PMID34836313
PMCPMC8617641

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.