ArticleNutrients2021
Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 4 citations in OpenAlex.
- Insights into Metabolically Healthy Obesity-A Narrative Review.Journal of clinical medicine · 2026Review
- Assessment of the Risk of Insulin Resistance in Workers Classified as Metabolically Healthy Obese.Nutrients · 2025Article
- Adherence to the Mediterranean diet as a possible additional tool to be used for screening the metabolically unhealthy obesity (MUO) phenotype.Journal of translational medicine · 2023Observational
- Metabolic phenotypes and risk of end-stage kidney disease in patients with type 2 diabetes.Frontiers in endocrinology · 2023Article
- Association of obesity and different metabolic status with prognosis in patients with bladder cancer: a retrospective cohort study.Therapeutic advances in urologyArticle
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundObesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution.
methodsThe CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention.
resultsInitially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (
conclusionsA greater loss of weight and liver fat is associated with a lower progression of the MHO phenotype to unhealthy phenotypes. Likewise, a marked improvement in these parameters is associated with regression from MUO to healthy phenotypes.
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