Evidence map›Paper›PMID 34836267›Full record

ReviewNutrients2021

The Role of Vitamin Deficiency in Liver Disease: To Supplement or Not Supplement?

Anna Licata, Maddalena Zerbo, Silvia Como, Marcella Cammilleri, Maurizio Soresi, Giuseppe Montalto, Lydia Giannitrapani

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Observational
  7. Article
  8. Article
  9. Cytopenias in Autoimmune Liver Diseases-A Review.Journal of clinical medicine · 2025
    Review
  10. Observational
  11. Article
  12. Review
  13. Article
  14. Metabolic Crosstalk between Liver and Brain: From Diseases to Mechanisms.International journal of molecular sciences · 2024
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Anna LicataInternal Medicine & Hepatology Section, Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties-PROMISE, University of Palermo Medical School, 90127 Palermo, Italy.ORCID 0000-0003-0383-6121
Maddalena ZerboInternal Medicine & Hepatology Section, Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties-PROMISE, University of Palermo Medical School, 90127 Palermo, Italy.ORCID 0000-0003-3646-5953
Silvia ComoInternal Medicine & Hepatology Section, Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties-PROMISE, University of Palermo Medical School, 90127 Palermo, Italy.ORCID 0000-0002-0139-9805
Marcella CammilleriInternal Medicine & Hepatology Section, Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties-PROMISE, University of Palermo Medical School, 90127 Palermo, Italy.
Maurizio SoresiInternal Medicine & Hepatology Section, Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties-PROMISE, University of Palermo Medical School, 90127 Palermo, Italy.ORCID 0000-0001-7850-555X
Giuseppe MontaltoInternal Medicine & Hepatology Section, Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties-PROMISE, University of Palermo Medical School, 90127 Palermo, Italy.
Lydia GiannitrapaniInternal Medicine & Hepatology Section, Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties-PROMISE, University of Palermo Medical School, 90127 Palermo, Italy.
University of Palermo · ITInstitute for Biomedical Research and Innovation · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past few years, growing interest has been shown for the impact of dietary requirements and nutritional factors on chronic diseases. As a result, nutritional programs have been reinforced by public health policies. The precise role of micronutrients in chronic liver disease is currently receiving particular attention since abnormalities in vitamin levels are often detected. At present, treatment programs are focused on correcting vitamin deficiencies, which are frequently correlated to higher rates of comorbidities with poor outcomes. The literature reviewed here indicates that liver diseases are often related to vitamin disorders, due to both liver impairment and abnormal intake. More specific knowledge about the role of vitamins in liver disease is currently emerging from various results and recent evidence. The most significant benefits in this area may be observed when improved vitamin intake is combined with a pharmacological treatment that may also affect the progression of the liver disease, especially in the case of liver tumors. However, further studies are needed.

Indexed as

Dietary SupplementsAscorbic Acid DeficiencyAvitaminosisHumansLiver DiseasesLiver TransplantationMalnutritionMicronutrientsNutritional RequirementsVitamin A DeficiencyVitamin D DeficiencyVitamin E DeficiencyVitamin K DeficiencyVitaminsMicronutrientsVitaminschronic liver diseasemicronutrientsvitaminsvitamin supplementation

Identifiers

PMID34836267
PMCPMC8620546
OpenAlexW3213324311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.