ArticleNutrients2021
Acute Paraxanthine Ingestion Improves Cognition and Short-Term Memory and Helps Sustain Attention in a Double-Blind, Placebo-Controlled, Crossover Trial.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
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Who cites it
17 citing papers in PubMed.
- Effects of six weeks of guanidinoacetic acid supplementation with and without creatine monohydrate on cognitive function and markers of health in healthy adults.Journal of the International Society of Sports Nutrition · 2026Trial
- Effects of creatine supplementation with and without exercise and diet intervention on body composition, cognitive function, and markers of health in middle-aged and older adults.Journal of the International Society of Sports Nutrition · 2026Trial
- Effects of a Plant-Based Multi-StrainNutrients · 2026Trial
- Paraxanthine provides greater improvement in cognitive function than caffeine after performing a 10-km run.Journal of the International Society of Sports Nutrition · 2024Trial
- Effects of Supplementation with a Microalgae Extract fromNutrients · 2024Trial
- Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood.Nutrients · 2024Trial
- Trial
- Dose-Response of Paraxanthine on Cognitive Function: A Double Blind, Placebo Controlled, Crossover Trial.Nutrients · 2021Trial
- Body fat percentage is a key factor in elevated plasma levels of caffeine and its metabolite in women.PeerJ · 2025Article
- Article
- Paraxanthine enhances memory and neuroplasticity more than caffeine in rats.Experimental brain research · 2024Article
- Nucleotide sugars correlate with leukocyte telomere length as part of a dyskeratosis congenita metabolomic plasma signature.Haematologica · 2024Article
- Polar licit and illicit ingredients in dietary supplements: chemometric optimization of extraction and HILIC-MS/MS analysis.Analytical and bioanalytical chemistry · 2024Article
- Paraxanthine safety and comparison to caffeine.Frontiers in toxicology · 2023Article
- Nutrition, lifestyle, and cognitive performance in esport athletes.Frontiers in nutrition · 2023Article
- Effects of Acute Ashwagandha Ingestion on Cognitive Function.International journal of environmental research and public health · 2022Article
- Paraxanthine Supplementation Increases Muscle Mass, Strength, and Endurance in Mice.Nutrients · 2022Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
This study examined the effects of acute paraxanthine (PXN) ingestion on markers of cognition, executive function, and psychomotor vigilance. In a randomized, double blind, placebo-controlled, crossover, and counterbalanced manner, 13 healthy male and female participants were randomly assigned to consume a placebo (PLA) or 200 mg of PXN (ENFINITY™, Ingenious Ingredients, L.P.). Participants completed stimulant sensitivity and side effect questionnaires and then performed the Berg Wisconsin Card Sorting Test (BCST), the Go/No-Go test (GNG), the Sternberg task test (STT), and the psychomotor vigilance task test (PVTT). Participants then ingested one capsule of PLA or PXN treatment. Participants completed side effect and cognitive function tests after 1, 2, 3, 4, 5, and 6 h after ingestion of the supplement. After 7 days, participants repeated the experiment while consuming the alternative treatment. Data were analyzed by general linear model (GLM) univariate analyses with repeated measures using body mass as a covariate, and by assessing mean and percent changes from baseline with 95% confidence intervals (CIs) expressed as means (LL, UL). PXN decreased BCST errors (PXN -4.7 [-0.2, -9.20],
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