Evidence map›Paper›PMID 34836216›Full record

ArticleNutrients2021

Length of Nutritional Transition Associates Negatively with Postnatal Growth in Very Low Birthweight Infants.

Lotta Immeli, Ulla Sankilampi, Pauliina M Mäkelä, Markus Leskinen, Reijo Sund, Sture Andersson, Päivi Luukkainen

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Relationship between feeding milestones and comorbidities with the postnatal growth in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  4. Article
  5. [Interpretation of the "Expert consensus on the management of neonatal parenteral nutrition (2025)"].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Article
  6. [Expert consensus on parenteral nutrition management in neonates (2025)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lotta ImmeliPediatric Research Center, New Children's Hospital, Helsinki University Hospital, University of Helsinki, 00290 Helsinki, Finland.ORCID 0000-0002-4052-2917
Ulla SankilampiDepartment of Pediatrics, Kuopio University Hospital, University of Eastern Finland, 70210 Kuopio, Finland.ORCID 0000-0002-0789-9720
Pauliina M MäkeläPediatric Research Center, New Children's Hospital, Helsinki University Hospital, University of Helsinki, 00290 Helsinki, Finland.
Markus LeskinenPediatric Research Center, New Children's Hospital, Helsinki University Hospital, University of Helsinki, 00290 Helsinki, Finland.
Reijo SundFaculty of Health Sciences, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
Sture AnderssonPediatric Research Center, New Children's Hospital, Helsinki University Hospital, University of Helsinki, 00290 Helsinki, Finland.
Päivi LuukkainenPediatric Research Center, New Children's Hospital, Helsinki University Hospital, University of Helsinki, 00290 Helsinki, Finland.ORCID 0000-0002-3953-4312
University of Helsinki · FIUniversity of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Very low birthweight (VLBW, <1500 g) infants may be predisposed to undernutrition during the nutritional transition phase from parenteral to enteral nutrition. We studied the associations among the length of the transition phase, postnatal macronutrient intake, and growth from birth to term equivalent age in VLBW infants. This retrospective cohort study included 248 VLBW infants born before 32 weeks of gestation and admitted to the Children's Hospital, Helsinki, Finland during 2005-2013. Daily nutrient intakes were obtained from computerized medication administration records. The length of the transition phase correlated negatively with cumulative energy, protein, fat, and carbohydrate intake at 28 days of age. It also associated negatively with weight and head circumference growth from birth to term equivalent age. For infants with a long transition phase (over 12 d), the estimates (95% CI) for weight and head circumference z-score change from birth to term equivalent age were -0.3 (-0.56, -0.04) and -0.44 (-0.81, -0.07), respectively, in comparison to those with a short transition phase (ad 7 d). For VLBW infants, rapid transition to full enteral feeding might be beneficial. However, if enteral nutrition cannot be advanced, well-planned parenteral nutrition during the transition phase is necessary to promote adequate growth.

Indexed as

Nutritional StatusEatingEnergy IntakeEnteral NutritionFemaleFinlandHumansInfantInfant, NewbornInfant Nutritional Physiological PhenomenaInfant, PrematureInfant, Very Low Birth WeightIntensive Care Units, NeonatalMaleMalnutritionParenteral Nutritionenteral nutritiongrowthnutritionparenteral nutritionpreterm infantstransition phasevery low birthweight infant

Identifiers

PMID34836216
PMCPMC8622897
OpenAlexW3213094743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.