Observational studyNutrients2021
Early Enteral Feeding Improves Tolerance of Parenteral Nutrition in Preterm Newborns.
Observational study in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Effect of Nasal Continuous Positive Airway Pressure vs Heated Humidified High-Flow Nasal Cannula on Feeding Intolerance in Preterm Infants With Respiratory Distress Syndrome: The ENTARES Randomized Clinical Trial.JAMA network open · 2023Trial
- Relationships of Early Parenteral Nutrition and Human Milk Fortification on the Growth of Neonates With Birth Weights Between 1500 and 1750 g.Journal of paediatrics and child health · 2026Article
- Refeeding Syndrome May Increase the Risk of Anemia of Prematurity: Is Early Enteral Nutrition the Solution?Nutrients · 2026Observational
- Calcium and Phosphorus Intake in Very Low Birth Weight Preterm Infants: Implications for Osteopenia Prevention and Growth.Pediatric gastroenterology, hepatology & nutrition · 2025Article
- Effect of early postoperative enteral nutrition on the short-term prognosis in neonatal gastric perforation.Pediatric discovery · 2025Article
- How long does it take to start minimal enteral feeding in preterm Neonates admitted to NICUs in Southern Oromia, Ethiopia?Italian journal of pediatrics · 2025Observational
- Early Enteral Feeding Restores Neurofilament Light Chain Serum Levels in Preterm Newborns.Current neuropharmacology · 2025Article
- Article
- Treatment-related problems in neonates receiving parenteral nutrition: risk factors and implications for practice.BMC pediatrics · 2024Article
- Feeding Intolerance in Critically Ill Patients with Enteral Nutrition: A Meta-Analysis and Systematic Review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Review
- Outcomes of postnatal systemic corticosteroids administration in ventilated preterm newborns: a systematic review of randomized controlled trials.Frontiers in pediatrics · 2024Review
- Dilemmas in establishing preterm enteral feeding: where do we start and how fast do we go?Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- The Impact of Estimated Energy and Protein Balances on Extrauterine Growth in Preterm Infants.Nutrients · 2023Article
- Early Energy Intake and Amino Acid Profile in Preterm Newborns: A Quasi-Experimental Study.Nutrients · 2023Article
- Nutritional status efficacy of early nutritional support in gastrointestinal care: A systematic review and meta-analysis.World journal of gastrointestinal surgery · 2023Article
- Analysis of risk factors for parenteral nutrition-associated cholestasis in preterm infants: a multicenter observational study.BMC pediatrics · 2023Observational
- Early oral feeding following intestinal anastomosis surgery in infants: a multicenter real world study.Frontiers in nutrition · 2023Article
- A Scoping Review: Urinary Markers of Metabolic Maturation in Preterm Infants and Future Interventions to Improve Growth.Nutrients · 2022Article
- Impact of Early Nutrient Intake and First Year Growth on Neurodevelopment of Very Low Birth Weight Newborns.Nutrients · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) Background: The tolerance of preterm newborns for the high nutritional intakes given by parenteral nutrition (PN) is still debated because of the risk of metabolic complications. Despite enteral nutrition (EN) being the preferred route of nutrition, an exclusive enteral feeding is not always possible, as in preterm newborns, the gut is immature and less tolerant of EN. We aimed to study the impact of a minimal enteral feeding (MEF) on the possible early metabolic complications of PN in a cohort of preterms with gestational age at birth GA ≤ 29 + 6/7 weeks of postmenstrual age. (2) Methods: We divided the study sample in two cohorts: 1) Late-Feeding (cohort 1), newborns who received MEF starting from the 8th day of age, and (2) Early-Feeding (cohort 2), newborns who received MEF, consisting of the administration of at least 4-5 mL/kg/day by the enteral route, in the first 7 days of age. The primary outcome of the study was the rate of at least one metabolic complication, including hyperglycemia, hypertriglyceridemia, or metabolic acidosis. (3) Results: We enrolled 80 newborns (Late-Feeding cohort 51 vs. Early-Feeding cohort 29). The rate of all metabolic complications was statistically higher in the Late-Feeding cohort compared to the Early-Feeding cohort. Binary logistic regression analysis showed that late administration of MEF negatively influenced the rate of all metabolic complications. (4) Conclusions: Early minimal administration of EN is associated with less frequent PN-related metabolic side effects and a higher rate of survival in critically ill newborns.
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Registered trials
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