Evidence map›Paper›PMID 34836050›Full record

ReviewNutrients2021

Early-Life Respiratory Infections in Infants with Cow's Milk Allergy: An Expert Opinion on the Available Evidence and Recommendations for Future Research.

Alessandro Fiocchi, Jan Knol, Sibylle Koletzko, Liam O'Mahony, Nikolaos G Papadopoulos, Seppo Salminen, Hania Szajewska, Anna Nowak-Węgrzyn

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 8 countries.

Alessandro FiocchiTranslational Research in Pediatric Specialities Area, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy.ORCID 0000-0002-2549-0523
Jan KnolDanone Nutricia Research, 3584 CT Utrecht, The Netherlands.ORCID 0000-0002-2103-5961
Sibylle KoletzkoDr von Hauner Kinderspital, University Hospital, LMU Klinikum, 80337 Munich, Germany.
Liam O'MahonyDepartment of Medicine, School of Microbiology, APC Microbiome Ireland National University of Ireland, T12 K8AF Cork, Ireland.
Nikolaos G PapadopoulosDivision of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester M13 9WL, UK.ORCID 0000-0002-4448-3468
Seppo SalminenFunctional Foods Forum, Faculty of Medicine, University of Turku, 20014 Turku, Finland.
Hania SzajewskaDepartment of Paediatrics, Medical University of Warsaw, 02-091 Warsaw, Poland.ORCID 0000-0002-4596-2874
Anna Nowak-WęgrzynDepartment of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, 10-719 Olsztyn, Poland.
Bambino Gesù Children's Hospital · ITDanone (Netherlands) · NLLMU Klinikum · DEMedical University of Warsaw · PLNational and Kapodistrian University of Athens · GRNational University of Ireland · IEUniversity of Turku · FIUniversity of Warmia and Mazury in Olsztyn · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute respiratory infections are a common cause of morbidity in infants and young children. This high rate of respiratory infections in early life has a major impact on healthcare resources and antibiotic use, with the associated risk of increasing antibiotic resistance, changes in intestinal microbiota composition and activity and, consequently, on the future health of children. An international group of clinicians and researchers working in infant nutrition and cow's milk allergy (CMA) met to review the available evidence on the prevalence of infections in healthy infants and in those with allergies, particularly CMA; the factors that influence susceptibility to infection in early life; links between infant feeding, CMA and infection risk; and potential strategies to modulate the gut microbiota and infection outcomes. The increased susceptibility of infants with CMA to infections, and the reported potential benefits with prebiotics, probiotics and synbiotics with regard to improving infection outcomes and reducing antibiotic usage in infants with CMA, makes this a clinically important issue that merits further research.

Indexed as

Anti-Bacterial AgentsDrug Resistance, MicrobialFemaleGastrointestinal MicrobiomeHumansInfantInfant, NewbornInfant Nutritional Physiological PhenomenaMaleMilk HypersensitivityPrevalenceProbioticsRespiratory Tract InfectionsAnti-Bacterial Agentsbreastfeedingcow’s milk allergydysbiosisinfant formulainfantsinfectionmicrobiotasynbioticupper respiratory tract infection

Identifiers

PMID34836050
PMCPMC8621023
OpenAlexW3209130742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.