Evidence map›Paper›PMID 34835970›Full record

Trial reportNutrients2021

Prevalence of Zinc Deficiency in Healthy 1-3-Year-Old Children from Three Western European Countries.

Mirjam Vreugdenhil, Marjolijn D Akkermans, Liandré F van der Merwe, Ruurd M van Elburg, Johannes B van Goudoever, Frank Brus

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Response to Comments from Brown et al. (ref: 2021EJCN0980RR).European journal of clinical nutrition · 2022
    Article
  7. Response to Correspondence from McDonald et al.European journal of clinical nutrition · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mirjam VreugdenhilDepartment of Pediatrics, Juliana Children's Hospital, Haga Teaching Hospital, 2545 AA The Hague, The Netherlands.
Marjolijn D AkkermansDepartment of Pediatrics, Juliana Children's Hospital, Haga Teaching Hospital, 2545 AA The Hague, The Netherlands.
Liandré F van der MerweDanone Nutricia Research, 3584 CT Utrecht, The Netherlands.ORCID 0000-0002-0964-7260
Ruurd M van ElburgDepartment of Pediatrics, Amsterdam UMC, Vrije Universiteit, University of Amsterdam Emma Children's Hospital, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0003-0310-6540
Johannes B van GoudoeverDepartment of Pediatrics, Amsterdam UMC, Vrije Universiteit, University of Amsterdam Emma Children's Hospital, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0003-3960-1703
Frank BrusDepartment of Pediatrics, Juliana Children's Hospital, Haga Teaching Hospital, 2545 AA The Hague, The Netherlands.
Haga Hospital · NLEmma Kinderziekenhuis · NLDanone (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc deficiency (ZnD) has adverse health consequences such as stunted growth. Since young children have an increased risk of developing ZnD, it is important to determine its prevalence and associated factors in this population. However, only a few studies have reported on ZnD prevalence in young children from Western high-income countries. This study evaluated ZnD prevalence and associated factors, including dietary Zn intake, in healthy 1-3-year-old children from Western European, high-income countries. ZnD was defined as serum Zn concentration <9.9 µmol/L. A total of 278 children were included with a median age of 1.7 years (Q1-Q3: 1.2-2.3). The median Zn concentration was 11.0 µmol/L (Q1-Q3: 9.0-12.2), and ZnD prevalence was 31.3%. No significant differences were observed in the socio-economic characteristics between children with and without ZnD. Dietary Zn intake was not associated with ZnD. ZnD is common in healthy 1-3-year-old children from Western European countries. However, the use of currently available cut-off values defining ZnD in young children has its limitations since these are largely based on reference values in older children. Moreover, these values were not evaluated in relation to health consequences, warranting further research.

Indexed as

Child, PreschoolEatingEuropeFemaleHumansInfantMalePrevalenceRisk FactorsZincZincchildrendietary zinc intakeWestern Europezinczinc deficiency

Identifiers

PMID34835970
PMCPMC8621620
OpenAlexW3209381699

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.