ReviewNanomaterials (Basel, Switzerland)2021
Iron, Copper, and Zinc Homeostasis: Physiology, Physiopathology, and Nanomediated Applications.
Review in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Natural Mineral Water (Hora) Supplementation Improves Growth Performance and Carcass Characteristics of Sheep in Ethiopia.Veterinary medicine and science · 2026Article
- The Multifaceted Properties of Copper and Zinc in Skin Healing.Dermatology and therapy · 2026Article
- The Preventive Effect of Zinc Sulfate against Olanzapine-Induced Testicular Toxicity in Male Rats.Biological trace element research · 2025Article
- Development of paper based colorimetric method using pigment from red dragon fruit for determination of Cu and Fe.Scientific reports · 2025Article
- Drought Response in the Transcriptome and Ionome of Wild and DomesticatedPlant-environment interactions (Hoboken, N.J.) · 2025Article
- Article
- Versatile Nanomaterials That Interfere with Ferroptosis in the Tumor Microenvironment.International journal of nanomedicine · 2025Review
- Association between serum copper and COPD: Insights from NHANES 2011-2016 and Mendelian randomization study.Tobacco induced diseases · 2025Article
- Copper deficiency myeloneuropathy associated to zinc supplementation: a case report.Acta neurologica Belgica · 2024Article
- Metal exposure in the Greenlandic ACCEPT cohort: follow-up and comparison with other Arctic populations.International journal of circumpolar health · 2024Article
- Metal ions overloading and cell death.Cell biology and toxicology · 2024Review
- Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies.Science advances · 2024Article
- Review
- Early Onset of Wilson's Disease and Possible Role of Disease-Modifying Genes: A Case Report and Literature Review.Case reports in hepatology · 2024Article
- Development and Evaluation of Zinc and Iron Nanoparticles Functionalized with Plant Growth-Promoting Rhizobacteria (PGPR) and Microalgae for Their Application as Bio-Nanofertilizers.Plants (Basel, Switzerland) · 2023Article
- Updated Mineral Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves fromPlants (Basel, Switzerland) · 2023Article
- Effects of Tocilizumab on Inflammation and Iron Metabolism in Critically Ill Patients with COVID-19.Pharmaceutics · 2023Article
- Hyperferritinemia, Low Circulating Iron and Elevated Hepcidin May Negatively Impact Outcome in COVID-19 Patients: A Pilot Study.Antioxidants (Basel, Switzerland) · 2022Article
- Elemental Composition of Commercial Herbal Tea Plants and Respective Infusions.Plants (Basel, Switzerland) · 2022Article
- Association between Severe SARS-CoV-2 Infection and Severe Acute Pancreatitis in Pregnancy and Postpartum.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Understanding of how the human organism functions has preoccupied researchers in medicine for a very long time. While most of the mechanisms are well understood and detailed thoroughly, medicine has yet much to discover. Iron (Fe), Copper (Cu), and Zinc (Zn) are elements on which organisms, ranging from simple bacteria all the way to complex ones such as mammals, rely on these divalent ions. Compounded by the continuously evolving biotechnologies, these ions are still relevant today. This review article aims at recapping the mechanisms involved in Fe, Cu, and Zn homeostasis. By applying the knowledge and expanding on future research areas, this article aims to shine new light of existing illness. Thanks to the expanding field of nanotechnology, genetic disorders such as hemochromatosis and thalassemia can be managed today. Nanoparticles (NPs) improve delivery of ions and confer targeting capabilities, with the potential for use in treatment and diagnosis. Iron deficiency, cancer, and sepsis are persisting major issues. While targeted delivery using Fe NPs can be used as food fortifiers, chemotherapeutic agents against cancer cells and microbes have been developed using both Fe and Cu NPs. A fast and accurate means of diagnosis is a major impacting factor on outcome of patients, especially when critically ill. Good quality imaging and bed side diagnostic tools are possible using NPs, which may positively impact outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.