Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth-Deferiprone Therapy against

Miguel Balado, Diego Rey-Varela, Ana M Albela, Manuel L Lemos

Open access · goldAbstract read

In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 58% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Miguel BaladoDepartment of Microbiology and Parasitology, Institute of Aquaculture, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0002-5702-4631

Diego Rey-VarelaDepartment of Microbiology and Parasitology, Institute of Aquaculture, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Ana M AlbelaDepartment of Microbiology and Parasitology, Institute of Aquaculture, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Manuel L LemosDepartment of Microbiology and Parasitology, Institute of Aquaculture, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0001-7964-2089

Universidade de Santiago de Compostela · ES

Funding

Xunta de Galicia GRC2018/018

6 · The paper itself

Abstract

Bismuth is a heavy metal with antibacterial properties that has a long history of medicinal use. The results reported here suggest that bismuth(III) (chelated with deferiprone) could be used in aquaculture systems to treat bacterial disease outbreaks, greatly reducing antibiotic use. We tested bismuth susceptibility in a collection of aquaculture bacterial pathogens. In the presence of bismuth concentrations ranging from 1.3 to 13 µM, most bacteria started showing a drastic decrease in their growth ability, although with high inter- and intraspecific variability. The minimal inhibitory concentrations of bismuth ranged from 13 to more than 780 µM, depending on bacterial species and strain. The results of in vivo assays suggest that low concentrations of bismuth could be especially effective to treat vibriosis caused by

Indexed as

aquaculturebacterial pathogensbismuthVibrio anguillarumvibriosis

Identifiers

PMID34835524

DOI10.3390/microorganisms9112399

PMCPMC8622636

OpenAlexW3217594512

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.