Evidence map›Paper›PMID 34835460›Full record

ArticleMicroorganisms2021

Bhalin, an Essential Cytoskeleton-Associated Protein of

Christine E Broster Reix, Célia Florimond, Anne Cayrel, Amélie Mailhé, Corentin Agnero-Rigot, Nicolas Landrein, Denis Dacheux, Katharina Havlicek, Mélanie Bonhivers, Brooke Morriswood and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Christine E Broster ReixProtist Parasite Cytoskeleton (ProParaCyto) Group, CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France.ORCID 0000-0002-9998-4577
Célia FlorimondProtist Parasite Cytoskeleton (ProParaCyto) Group, CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France.
Anne CayrelProtist Parasite Cytoskeleton (ProParaCyto) Group, CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France.ORCID 0000-0003-2067-3272
Amélie MailhéProtist Parasite Cytoskeleton (ProParaCyto) Group, CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France.
Corentin Agnero-RigotProtist Parasite Cytoskeleton (ProParaCyto) Group, CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France.
Nicolas LandreinProtist Parasite Cytoskeleton (ProParaCyto) Group, CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France.ORCID 0000-0001-8875-4242
Denis DacheuxProtist Parasite Cytoskeleton (ProParaCyto) Group, CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France.
Katharina HavlicekMax Perutz Labs, Vienna BioCenter, Dr. Bohr-Gasse 9, 1030 Vienna, Austria.
Mélanie BonhiversProtist Parasite Cytoskeleton (ProParaCyto) Group, CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France.ORCID 0000-0001-9179-8473
Brooke MorriswoodDepartment of Cell and Developmental Biology, Biocenter, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany.
Derrick R RobinsonProtist Parasite Cytoskeleton (ProParaCyto) Group, CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France.
Centre National de la Recherche Scientifique · FRMax Perutz Labs · ATUniversity of Würzburg · DE

Funding

Agence Nationale de la Recherche ANR-10-INBS-04Agence Nationale de la Recherche ANR-11-LABX-0024Agence Nationale de la Recherche ANR-20-CE91-0003Centre National de la Recherche Scientifique CNRS UMR5234MESRI PhD fellowshipUniversity of Bordeaux UMR5234
6 · The paper itself

Abstract

backgroundIn most trypanosomes, endo and exocytosis only occur at a unique organelle called the flagellar pocket (FP) and the flagellum exits the cell via the FP. Investigations of essential cytoskeleton-associated structures located at this site have revealed a number of essential proteins. The protein METHODOLOGY/PRINCIPAL

findingsHere, we show that a newly characterised protein, BHALIN (BILBO1 Hook Associated LINker protein), is localised to both the FPC and HC and has a CONCLUSIONS/SIGNIFICANCE: Our results demonstrate the essential role of a newly characterised hook complex protein, BHALIN, that influences flagellar pocket organisation and function in bloodstream form

Indexed as

cytoskeletonendocytosisflagellar pocketflagellar pocket collarhook complexprotozoantrypanosoma

Identifiers

PMID34835460
PMCPMC8623173
OpenAlexW3213092848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.