Evidence map›Paper›PMID 34835431›Full record

ReviewMicroorganisms2021

Serological Responses to Influenza Vaccination during Pregnancy.

Ana Vazquez-Pagan, Stacey Schultz-Cherry

Abstract readReview
In one paragraph

Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ana Vazquez-PaganGraduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-9984-7129
Stacey Schultz-CherryGraduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-2021-727X

Funding

Effects of obesity on the dynamics of Influenza transmissionR01AI140766 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GRESHAM, DAVID, SCHULTZ-CHERRY, STACEY L · 2019 to 2023
$4.1M
American Lebanese Syrian Associated Charities NANational Institute of Allergy and Infectious Diseases 75N93019C0052National Institute of Allergy and Infectious Diseases HHSN27220140006CNational Institute of Allergy and Infectious Diseases R01AI140766NIAID NIH HHS R01 AI140766St Jude Graduate School of Biomedical Sciences NA
6 · The paper itself

Abstract

Pregnant women, newborns, and infants under six months old are at the highest risk of developing severe and even fatal influenza. This risk is compounded by the inability to vaccinate infants under six months, highlighting the importance of vertically transferred immunity. This review identifies novel insights that have emerged from recent studies using animal models of pregnancy and vaccination. We also discuss the knowledge obtained using existing clinical trials that have evaluated influenza-specific serological responses in pregnant women and how these responses may impact early life immunity. We delineate the mechanisms involved in transferring specific maternal antibodies and discuss the consequences for early life immunity. Most importantly, we highlight the need for continued research using pregnant animal models and the inclusion of pregnant women, a commonly neglected population, when evaluating novel vaccine platforms to better serve and treat communicable diseases.

Indexed as

early life immunityimmunological bluntinginfluenza vaccinematernal antibody interferencepassive immunityplacentapregnancy

Identifiers

PMID34835431
PMCPMC8619416

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.