Evidence map›Paper›PMID 34835393›Full record

ReviewMicroorganisms2021

Cellular Self-Digestion and Persistence in Bacteria.

Sayed Golam Mohiuddin, Sreyashi Ghosh, Han G Ngo, Shayne Sensenbach, Prashant Karki, Narendra K Dewangan, Vahideh Angardi, Mehmet A Orman

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Teicoplanin associated geneFrontiers in microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sayed Golam MohiuddinDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77004, USA.
Sreyashi GhoshDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77004, USA.ORCID 0000-0002-0346-7381
Han G NgoDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77004, USA.ORCID 0000-0002-3860-4550
Shayne SensenbachDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77004, USA.ORCID 0000-0003-4955-9596
Prashant KarkiDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77004, USA.
Narendra K DewanganDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77004, USA.ORCID 0000-0002-9124-9789
Vahideh AngardiDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77004, USA.
Mehmet A OrmanDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77004, USA.
University of Houston · US

Funding

Characterizing a Self-Digesting-Mediated Reversible Drug Tolerance Mechanism in BacteriaR01AI143643 · NIAID · UNIVERSITY OF HOUSTON · PI ORMAN, MEHMET A. · 2020 to 2024
$1.9M
National Institute of Health R01-AI143643-01A1NIAID NIH HHS R01 AI143643
6 · The paper itself

Abstract

Cellular self-digestion is an evolutionarily conserved process occurring in prokaryotic cells that enables survival under stressful conditions by recycling essential energy molecules. Self-digestion, which is triggered by extracellular stress conditions, such as nutrient depletion and overpopulation, induces degradation of intracellular components. This self-inflicted damage renders the bacterium less fit to produce building blocks and resume growth upon exposure to fresh nutrients. However, self-digestion may also provide temporary protection from antibiotics until the self-digestion-mediated damage is repaired. In fact, many persistence mechanisms identified to date may be directly or indirectly related to self-digestion, as these processes are also mediated by many degradative enzymes, including proteases and ribonucleases (RNases). In this review article, we will discuss the potential roles of self-digestion in bacterial persistence.

Indexed as

autophagybacterial persistersintracellular degradationlipid degradationprotein degradationRNA degradationself-digestionstationary-phase metabolismviable but non-culturable cells

Identifiers

PMID34835393
PMCPMC8626048
OpenAlexW3208084960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.