Evidence map›Paper›PMID 34835341›Full record

ArticleMicroorganisms2021

Pilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts.

Haryung Park, Karina Arellano, Yuri Lee, Subin Yeo, Yosep Ji, Joontae Ko, Wilhelm Holzapfel

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Skin and gut microbiome in atopic dermatitis: Mechanisms and therapeutic opportunities.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Frontiers in pharmacology · 2025
    Article
  11. Article
  12. The Gut and Skin Microbiome and Its Association with Aging Clocks.International journal of molecular sciences · 2024
    Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Haryung ParkDepartment of Advanced Convergence, Handong Global University, Pohang 37554, Korea.
Karina ArellanoDepartment of Advanced Convergence, Handong Global University, Pohang 37554, Korea.
Yuri LeeDepartment of Advanced Convergence, Handong Global University, Pohang 37554, Korea.
Subin YeoHEM Pharma Inc., Start-Up Incubator, Handong Global University, Pohang 37554, Korea.
Yosep JiDepartment of Advanced Convergence, Handong Global University, Pohang 37554, Korea.
Joontae KoBoaz Medical Hospital, Handong Global University, Pohang 37554, Korea.
Wilhelm HolzapfelDepartment of Advanced Convergence, Handong Global University, Pohang 37554, Korea.ORCID 0000-0002-3669-1419
Handong Global University · KR

Funding

Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea HP20C0029
6 · The paper itself

Abstract

Dry skin is one of the indicators of a compromised skin barrier. An intact skin barrier is not only important to reserve the hydration within the epidermal tissue but also to protect our skin from environmental stressors and inhibit pathogen invasion; damage to the skin barrier may lead to inflammatory skin diseases. Some microbial metabolites such as short chain fatty acids may inhibit or destroy harmful bacteria and regulate the host immune system. The impact of the skin microbiome and short chain fatty acids on skin barrier function was studied in two groups of 75 participants each. The cohort was equally divided in dry and moist skin types, based on stratum corneum (SC) functionality index (SCFI), reflecting the ratio of transepidermal water loss (TEWL). A dry group represents a low SCFI and a moist group a high SCFI. Compared with the dry skin group, propionate and

Indexed as

Cutibacteriumdiversitydrymoistshort chain fatty acidsskin microbiomeStaphylococcus

Identifiers

PMID34835341
PMCPMC8617931
OpenAlexW3208209062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.