Evidence map›Paper›PMID 34835281›Full record

ArticleVaccines2021

ISCOM-like Nanoparticles Formulated with

Mariana Rivera-Patron, María Moreno, Mariana Baz, Paulo M Roehe, Samuel P Cibulski, Fernando Silveira

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Mucosal immunity and vaccine development.Signal transduction and targeted therapy · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Leaf Saponins ofPharmaceutics · 2025
    Review
  6. Review
  7. Intranasal Delivery ofVaccines · 2024
    Article
  8. Article
  9. Review
  10. Frontiers in immunology · 2023
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Mariana Rivera-PatronDepartamento de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República (UdelaR), Montevideo 11600, Uruguay.
María MorenoDepartamento de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República (UdelaR), Montevideo 11600, Uruguay.ORCID 0000-0002-7294-6693
Mariana BazResearch Center in Infectious Diseases of the CHU of Québec and Université Laval, Quebec City, QC G1V 4G2, Canada.ORCID 0000-0002-1230-0735
Paulo M RoeheDepartamento de Microbiologia Imunologia e Parasitologia, Laboratório de Virologia, UFRGS, Porto Alegre 90050-170, Brazil.ORCID 0000-0002-2370-7661
Samuel P CibulskiDepartamento de Microbiologia Imunologia e Parasitologia, Laboratório de Virologia, UFRGS, Porto Alegre 90050-170, Brazil.ORCID 0000-0003-0503-8692
Fernando SilveiraDepartamento de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República (UdelaR), Montevideo 11600, Uruguay.ORCID 0000-0002-6980-8265
Universidad de la República de Uruguay · UYUniversidade Federal do Rio Grande do Sul · BRUniversité Laval · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccination is the most effective public health intervention to prevent influenza infections, which are responsible for an important burden of respiratory illnesses and deaths each year. Currently, licensed influenza vaccines are mostly split inactivated, although in order to achieve higher efficacy rates, some influenza vaccines contain adjuvants. Although split-inactivated vaccines induce mostly humoral responses, tailoring mucosal and cellular immune responses is crucial for preventing influenza infections.

Indexed as

adjuvantsdose-sparing effectinfluenza virusISCOMsQuillaja brasiliensis

Identifiers

PMID34835281
PMCPMC8621233
OpenAlexW3213513603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.