Evidence map›Paper›PMID 34835256›Full record

ArticleVaccines2021

Thrombotic Adverse Events Reported for Moderna, Pfizer and Oxford-AstraZeneca COVID-19 Vaccines: Comparison of Occurrence and Clinical Outcomes in the EudraVigilance Database.

Mansour Tobaiqy, Katie MacLure, Hajer Elkout, Derek Stewart

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 47 citations in OpenAlex.

  1. Long-term outcomes after using retrievable vena cava filters in major trauma patients with contraindications to prophylactic anticoagulation.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023
    Trial
  2. Article
  3. The strategies and advances of mRNA translation booster.Asian journal of pharmaceutical sciences · 2025
    Review
  4. Review
  5. Observational
  6. Observational
  7. Article
  8. Annals of medicine and surgery (2012) · 2023
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Carotid free-floating thrombus during COVID-19 vaccine era: causality or not?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  15. Adverse Events and Safety of SARS-CoV-2 Vaccines: What's New and What's Next.The journal of allergy and clinical immunology. In practice · 2022
    Review
  16. Article
  17. Public Health Management of the COVID-19 Pandemic in Australia: The Role of the Morrison Government.International journal of environmental research and public health · 2022
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 4 countries.

Mansour TobaiqyDepartment of Pharmacology, College of Medicine, University of Jeddah, Jeddah P.O. Box 45311, Saudi Arabia.ORCID 0000-0002-4292-0900
Katie MacLureIndependent Researcher, Aberdeen AB32 6RU, UK.ORCID 0000-0003-0686-948X
Hajer ElkoutDepartment of Family and Community Medicine, Medical Faculty, University of Tripoli, Tripoli P.O. Box 13662, Libya.ORCID 0000-0003-3191-3868
Derek StewartCollege of Pharmacy, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0001-7360-8592
Qatar University · QAUniversity of Aberdeen · GBUniversity of Jeddah · SAUniversity of Tripoli · LY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccination against COVID-19 is the cornerstone of controlling and mitigating the ongoing pandemic. Thrombotic adverse events linked to Moderna, Pfizer and the Oxford-AstraZeneca vaccine have been documented and described as extremely rare. While the Oxford-AstraZeneca vaccine has received much of the attention, the other vaccines should not go unchallenged. This study aimed to determine the frequency of reported thrombotic adverse events and clinical outcomes for these three COVID-19 vaccines, namely, Moderna, Pfizer and Oxford-AstraZeneca. A retrospective descriptive analysis was conducted of spontaneous reports for Moderna, Pfizer and Oxford-AstraZeneca COVID-19 vaccines submitted to the EudraVigilance database in the period from 17 February to 14 June 2021. There were 729,496 adverse events for the three vaccines, of which 3420 were thrombotic, mainly Oxford-AstraZeneca (n = 1988; 58.1%) followed by Pfizer (n = 1096; 32.0%) and Moderna (n = 336; 9.8%). As serious adverse events, there were 705 reports of pulmonary embolism for the three vaccines, of which 130 reports (18.4%) were for Moderna, 226 reports (32.1%) for Pfizer and 349 (49.5%) for Oxford-AstraZeneca vaccines. The occurrence of pulmonary embolism is significantly associated with a fatal outcome (

Indexed as

adverse drug reactionadverse eventsAstraZenacaCOVID-19 vaccineModernaPfizerthrombotic

Identifiers

PMID34835256
PMCPMC8624459
OpenAlexW3213661868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.