Evidence map›Paper›PMID 34835194›Full record

ReviewVaccines2021

Cervical Cancer Protection in Japan: Where Are We?

Asami Yagi, Yutaka Ueda, Mamoru Kakuda, Satoshi Nakagawa, Kosuke Hiramatsu, Ai Miyoshi, Eiji Kobayashi, Toshihiro Kimura, Megumi Kurosawa, Manako Yamaguchi and 9 more

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
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  6. The effects of human papillomavirus vaccination in Japan.Human vaccines & immunotherapeutics · 2025
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  8. Cost-effectiveness analysis of 9-valent human papillomavirus vaccine combined with screening for cervical cancer in Japan.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Asami YagiDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
Yutaka UedaDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.ORCID 0000-0001-8760-6379
Mamoru KakudaDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.ORCID 0000-0003-2768-8848
Satoshi NakagawaDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
Kosuke HiramatsuDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.ORCID 0000-0001-7569-7875
Ai MiyoshiDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
Eiji KobayashiDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
Toshihiro KimuraDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
Megumi KurosawaDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Manako YamaguchiDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Sosuke AdachiDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Risa KudoDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Masayuki SekineDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.ORCID 0000-0003-0751-6395
Yukio SuzukiDepartment of Obstetrics and Gynecology, Yokohama City University School of Medical, Yokohama 236-0004, Japan.
Akiko SukegawaDepartment of Obstetrics and Gynecology, Yokohama City University School of Medical, Yokohama 236-0004, Japan.
Sayaka IkedaDivision of Cancer Statistics Integration, Center for Cancer Control and Information Services, National Cancer Center, Tokyo 104-0045, Japan.
Etsuko MiyagiDepartment of Obstetrics and Gynecology, Yokohama City University School of Medical, Yokohama 236-0004, Japan.ORCID 0000-0002-5492-0844
Takayuki EnomotoDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Tadashi KimuraDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
The University of Osaka · JPNiigata University · JPYokohama City University · JP

Funding

Japan Agency for Medical Research and Development #21ck0106562h0002Ministry of Health Labour and Welfare #20EA1025
6 · The paper itself

Abstract

In Japan, government subsidies for human papillomavirus (HPV) vaccination of girls aged 13-16 commenced in 2010. By early 2013, vaccination had become a widely accepted national immunization program. However, in June of 2013, the Ministry of Health, Labor, and Welfare (MHLW), the government's lead agency, suspended its recommendation for vaccination in response to reports of adverse vaccine events. The rate of HPV vaccination quickly dropped from 70% to almost zero, where it has lingered for eight years. In 2020, a new 9-valent HPV vaccine was licensed in Japan. The momentum seemed to be building for the resumption of HPV vaccinations, yet Japanese mothers remain widely hesitant about vaccinating their daughters, despite the well-proven safety and efficacy of the HPV vaccines. The Japanese government and our educational and medical institutions must work harder as a team to inform our parents and their children about the life-saving benefits of the HPV vaccine, and at the same time, we must respond to all their concerns and questions. The vaccine hesitancy of unvaccinated women born in 2000 and thereafter is a natural consequence of the suspension of the government's recommendation. We must also take every possible measure to reduce the significant risk for cervical cancer these women have.

Indexed as

adverse eventscervical cancergovernment suspension of recommendationHPV vaccinevaccine hesitancy

Identifiers

PMID34835194
PMCPMC8619953
OpenAlexW3208338667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.