Evidence map›Paper›PMID 34835131›Full record

ArticleViruses2021

Cross-Reactive Antibodies to SARS-CoV-2 and MERS-CoV in Pre-COVID-19 Blood Samples from Sierra Leoneans.

Rodrigo Borrega, Diana K S Nelson, Anatoliy P Koval, Nell G Bond, Megan L Heinrich, Megan M Rowland, Raju Lathigra, Duane J Bush, Irina Aimukanova, Whitney N Phinney and 32 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 5 institutions in 3 countries.

Rodrigo BorregaZalgen Labs, LCC, Germantown, MD 20876, USA.ORCID 0000-0001-7627-7223
Diana K S NelsonZalgen Labs, LCC, Broomfield, CO 80045, USA.
Anatoliy P KovalZalgen Labs, LCC, Germantown, MD 20876, USA.
Nell G BondDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-4996-4025
Megan L HeinrichZalgen Labs, LCC, Germantown, MD 20876, USA.
Megan M RowlandZalgen Labs, LCC, Germantown, MD 20876, USA.
Raju LathigraZalgen Labs, LCC, Germantown, MD 20876, USA.
Duane J BushZalgen Labs, LCC, Broomfield, CO 80045, USA.
Irina AimukanovaZalgen Labs, LCC, Broomfield, CO 80045, USA.
Whitney N PhinneyZalgen Labs, LCC, Broomfield, CO 80045, USA.
Sophia A KovalZalgen Labs, LCC, Germantown, MD 20876, USA.
Andrew R HoffmannDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-9374-4740
Allison R SmitherDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Antoinette R Bell-KareemDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Lilia I MelnikDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Kaylynn J GenemarasDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Karissa ChaoDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Patricia SnarskiHeart and Vascular Institute, John W. Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-2470-7655
Alexandra B MeltonDepartment of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA.
Jaikin E HarrellDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-2194-3978
Ashley A SmiraDepartment of Pediatrics, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Debra H ElliottDepartment of Pediatrics, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Julie A RouelleDepartment of Pediatrics, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Gilberto Sabino-SantosDepartment of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-5462-5386
Arnaud C DrouinDepartment of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Mambu MomohEastern Polytechnic Institute, Kenema, Sierra Leone.
John Demby SandiViral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.
Augustine GobaViral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.
Robert J SamuelsViral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.
Lansana KannehViral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.
Michael GbakieViral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.
Zoe L BrancoZalgen Labs, LCC, Germantown, MD 20876, USA.
Jeffrey G ShafferDepartment of Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-3941-3772
John S SchieffelinDepartment of Pediatrics, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
James E RobinsonDepartment of Pediatrics, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Dahlene N FuscoDepartment of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Pardis C SabetiBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Kristian G AndersenDepartment of Immunology and Microbial Science, Scripps Research, La Jolla, CA 92037, USA.
Donald S GrantViral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.ORCID 0000-0002-4329-0795
Matthew L BoisenZalgen Labs, LCC, Broomfield, CO 80045, USA.
Luis M BrancoZalgen Labs, LCC, Germantown, MD 20876, USA.ORCID 0000-0001-8161-0182
Robert F GarryZalgen Labs, LCC, Germantown, MD 20876, USA.ORCID 0000-0002-5683-3250
Tulane University · USZalgen (United States) · USUniversity of Sierra Leone · SLBroad Institute · USScripps Research Institute · US

Funding

Technology CoreU19AI135995 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Robert F Garry · 2018 to 2026
$32.0M
West African Emerging Infectious Disease Research Center (WA-EIDRC)U01AI151812 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ANDERSEN, KRISTIAN GRAUGAARD, GARRY, ROBERT F · 2020 to 2024
$13.2M
Tulane University COVID Antibody and Immunity Network (TUCAIN) SupplementU54CA260581 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI ROBINSON, JAMES E · 2020 to 2024
$9.2M
NCI NIH HHS U54 CA260581NIAID NIH HHS U01 AI151812NIAID NIH HHS U19 AI135995NIH HHS 1R01 AI123535NIH HHS U19AI135995 and U19AI151812, and 1R01AI123535NIH HHS U19 AI151812
6 · The paper itself

Abstract

Many countries in sub-Saharan Africa have experienced lower COVID-19 caseloads and fewer deaths than countries in other regions worldwide. Under-reporting of cases and a younger population could partly account for these differences, but pre-existing immunity to coronaviruses is another potential factor. Blood samples from Sierra Leonean Lassa fever and Ebola survivors and their contacts collected before the first reported COVID-19 cases were assessed using enzyme-linked immunosorbent assays for the presence of antibodies binding to proteins of coronaviruses that infect humans. Results were compared to COVID-19 subjects and healthy blood donors from the United States. Prior to the pandemic, Sierra Leoneans had more frequent exposures than Americans to coronaviruses with epitopes that cross-react with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), SARS-CoV, and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). The percentage of Sierra Leoneans with antibodies reacting to seasonal coronaviruses was also higher than for American blood donors. Serological responses to coronaviruses by Sierra Leoneans did not differ by age or sex. Approximately a quarter of Sierra Leonian pre-pandemic blood samples had neutralizing antibodies against SARS-CoV-2 pseudovirus, while about a third neutralized MERS-CoV pseudovirus. Prior exposures to coronaviruses that induce cross-protective immunity may contribute to reduced COVID-19 cases and deaths in Sierra Leone.

Indexed as

Age DistributionAlphacoronavirusAntibodies, NeutralizingAntibodies, ViralAntigens, ViralBetacoronavirusBlood DonorsCoronavirus Nucleocapsid ProteinsCOVID-19Cross ProtectionCross ReactionsEpitopesFemaleHumansMaleMiddle East Respiratory Syndrome CoronavirusAntibodies, NeutralizingAntibodies, ViralAntigens, ViralCoronavirus Nucleocapsid ProteinsEpitopesnucleocapsid phosphoprotein, SARS-CoV-2PhosphoproteinsCOVID-19 caseloads and deathsenzyme-linked immunosorbent assaysMiddle Eastern respiratory syndrome coronaviruspre-existing immunity to coronavirusespseudovirus neutralizing antibodiesrecombinant antigenssevere acute respiratory syndrome coronavirus-2sub-Saharan Africa

Identifiers

PMID34835131
PMCPMC8625389
OpenAlexW3216193357

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.