Evidence map›Paper›PMID 34835060›Full record

ArticleViruses2021

Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast.

Átila Duque Rossi, Fabio Rueda Faucz, Adriana Melo, Girlene Souza de Azevedo, Paula Pezzuto, Ohanna Cavalcanti de Lima Bezerra, Fernanda Saloum de Neves Manta, Tamiris Azamor, Bruno Luiz Fonseca Schamber-Reis, Amilcar Tanuri and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Microbiota-dependent IFN-L controls uterine and placental immunity.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Átila Duque RossiLaboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID 0000-0001-6235-8807
Fabio Rueda FauczSection on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA.ORCID 0000-0001-7959-9842
Adriana MeloInstituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ), Campina Grande 58406-115, Brazil.
Girlene Souza de AzevedoInstituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ), Campina Grande 58406-115, Brazil.
Paula PezzutoLaboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID 0000-0001-9570-8244
Ohanna Cavalcanti de Lima BezerraLaboratório de Hanseníase, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0002-0798-778X
Fernanda Saloum de Neves MantaLaboratório de Hanseníase, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro 21040-900, Brazil.
Tamiris AzamorLaboratório de Hanseníase, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro 21040-900, Brazil.
Bruno Luiz Fonseca Schamber-ReisFaculdade de Ciências Médicas de Campina Grande, Núcleo de Genética Médica, Centro Universitário UniFacisa, Campina Grande 58408-326, Brazil.
Amilcar TanuriLaboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID 0000-0003-0570-750X
Milton Ozório MoraesLaboratório de Hanseníase, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro 21040-900, Brazil.
Renato Santana AguiarLaboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID 0000-0001-5180-3717
Constantine A StratakisSection on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA.ORCID 0000-0002-4058-5520
Cynthia Chester CardosoLaboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID 0000-0003-0565-7047
Fundação Oswaldo Cruz · BRUniversidade Federal do Rio de Janeiro · BRInstituto de Tecnologia e Pesquisa · BRNational Institutes of Health · USUniversidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital Zika syndrome (CZS) is characterized by a diverse group of congenital malformations induced by ZIKV infection during pregnancy. Type III interferons have been associated with placental immunity against ZIKV and restriction of vertical transmission in mice, and non-coding single-nucleotide polymorphisms (SNPs) on these genes are well known to influence susceptibility to other viral infections. However, their effect on ZIKV pathogenesis has not yet been explored. To investigate whether maternal non-coding SNPs at

Indexed as

AllelesBrazilCase-Control StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansInterferon LambdaInterferonsInterleukinsPolymorphism, Single NucleotidePregnancyPregnancy Complications, InfectiousZika VirusZika Virus InfectionInterferon Lambdainterferon-lambda, humanInterferonsInterleukinscongenital Zika syndromegenetic susceptibilitypolymorphismtype III interferonZika

Identifiers

PMID34835060
PMCPMC8622836
OpenAlexW3213284092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.