Evidence map›Paper›PMID 34834942›Full record

ArticleViruses2021

Species-Specific Inhibition of Necroptosis by HCMV UL36.

Elena Muscolino, Claudia Castiglioni, Renke Brixel, Giada Frascaroli, Wolfram Brune

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Cell death network regulation in HSV infection: immune evasion versus host defense.Apoptosis : an international journal on programmed cell death · 2026
    Review
  3. Article
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  5. Article
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  7. Article
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  10. Review
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  13. Article
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  15. Role of necroptosis in kidney health and disease.Nature reviews. Nephrology · 2023
    Review
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Elena MuscolinoLeibniz Institute for Experimental Virology (HPI), 20251 Hamburg, Germany.ORCID 0000-0003-4519-9415
Claudia CastiglioniLeibniz Institute for Experimental Virology (HPI), 20251 Hamburg, Germany.
Renke BrixelLeibniz Institute for Experimental Virology (HPI), 20251 Hamburg, Germany.ORCID 0000-0002-7737-3505
Giada FrascaroliLeibniz Institute for Experimental Virology (HPI), 20251 Hamburg, Germany.ORCID 0000-0001-8186-7594
Wolfram BruneLeibniz Institute for Experimental Virology (HPI), 20251 Hamburg, Germany.ORCID 0000-0002-6078-5255
Leibniz Institute of Virology (LIV) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral infection activates cellular antiviral defenses including programmed cell death (PCD). Many viruses, particularly those of the

Indexed as

NecroptosisAnimalsApoptosisCell LineCytomegalovirusHerpesviridaeHerpesvirus 1, HumanHost-Pathogen InteractionsMiceMolluscum contagiosum virusMuromegalovirusNecrosisSpecies SpecificityViral ProteinsUL36 protein, Human herpesvirus 1Viral ProteinsapoptosisHCMVherpesvirusICP6M45MCMVMLKLnecroptosisRIPK1RIPK3UL36

Identifiers

PMID34834942
PMCPMC8621378
OpenAlexW3209268260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.