Evidence map›Paper›PMID 34834915›Full record

ArticleViruses2021

Direct RNA Sequencing Reveals SARS-CoV-2 m6A Sites and Possible Differential DRACH Motif Methylation among Variants.

João H C Campos, Juliana T Maricato, Carla T Braconi, Fernando Antoneli, Luiz Mario R Janini, Marcelo R S Briones

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. SARS-CoV-2 reshapes mNAR molecular medicine · 2025
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  4. Review
  5. Article
  6. Review
  7. Article
  8. Epigenetic regulation of pulmonary inflammation.Seminars in cell & developmental biology · 2024
    Review
  9. Direct Analysis of HIV mRNA mMethods in molecular biology (Clifton, N.J.) · 2024
    Article
  10. NCellular & molecular biology letters · 2023
    Review
  11. Review
  12. Insight into the mechanisms of coronaviruses evading host innate immunity.Biochimica et biophysica acta. Molecular basis of disease · 2023
    Review
  13. No evidence for epitranscriptomic mRNA (New York, N.Y.) · 2023
    Article
  14. Article
  15. EpitranscriptomicMicrobiology spectrum · 2023
    Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

João H C CamposCenter for Medical Bioinformatics, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), São Paulo 04039032, Brazil.ORCID 0000-0002-8590-8442
Juliana T MaricatoDepartment of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), São Paulo 04023062, Brazil.ORCID 0000-0002-3631-2247
Carla T BraconiDepartment of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), São Paulo 04023062, Brazil.ORCID 0000-0002-5370-8980
Fernando AntoneliCenter for Medical Bioinformatics, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), São Paulo 04039032, Brazil.ORCID 0000-0001-9179-4632
Luiz Mario R JaniniDepartment of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), São Paulo 04023062, Brazil.ORCID 0000-0002-6186-6284
Marcelo R S BrionesCenter for Medical Bioinformatics, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), São Paulo 04039032, Brazil.ORCID 0000-0001-8045-2477
Universidade Federal de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 303912/2017-0Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 405691/2018-1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2020/08943-5
6 · The paper itself

Abstract

The causative agent of COVID-19 pandemic, SARS-CoV-2, has a 29,903 bases positive-sense single-stranded RNA genome. RNAs exhibit about 150 modified bases that are essential for proper function. Among internal modified bases, the

Indexed as

3' Untranslated RegionsAdenosineAnimalsChlorocebus aethiopsCOVID-19Genome, ViralHumansImmune EvasionMethylationNanopore SequencingOpen Reading FramesRNA, ViralSARS-CoV-2Sequence Analysis, RNAVero Cells3' Untranslated RegionsAdenosineN-methyladenosineRNA, ViralCOVID-19direct RNA sequencingEpitranscriptomicsm6ARNA methylationSARS-CoV-2

Identifiers

PMID34834915
PMCPMC8620083
OpenAlexW3206002465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.