Evidence map›Paper›PMID 34834569›Full record

ArticleJournal of personalized medicine2021

Synergistic Mutations of

Kuan-Yu Chu, Yin-Lin Wang, Yu-Ren Chou, Jung-Tsu Chen, Yi-Ping Wang, James P Simmer, Jan C-C Hu, Shih-Kai Wang

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Exonic and IntronicDiagnostics (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Critical Considerations in Calling Disease-CausingJournal of clinical medicine · 2024
    Article
  6. Review
  7. Article
  8. PAX9 mutations and genetic synergism in familial tooth agenesis.Annals of the New York Academy of Sciences · 2023
    Article
  9. Tooth number abnormality: from bench to bedside.International journal of oral science · 2023
    Review
  10. Article
  11. The role of WNT10B in physiology and disease: A 10-year update.Frontiers in cell and developmental biology · 2023
    Review
  12. Review
  13. International journal of molecular sciences · 2022
    Article
  14. Article
  15. NovelJournal of personalized medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Kuan-Yu ChuDepartment of Dentistry, School of Dentistry, National Taiwan University, Taipei City 100, Taiwan.
Yin-Lin WangDepartment of Dentistry, School of Dentistry, National Taiwan University, Taipei City 100, Taiwan.ORCID 0000-0001-6790-1311
Yu-Ren ChouGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei City 106, Taiwan.
Jung-Tsu ChenDepartment of Dentistry, School of Dentistry, National Taiwan University, Taipei City 100, Taiwan.
Yi-Ping WangDepartment of Dentistry, School of Dentistry, National Taiwan University, Taipei City 100, Taiwan.
James P SimmerDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48108, USA.
Jan C-C HuDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48108, USA.ORCID 0000-0002-9294-0248
Shih-Kai WangDepartment of Dentistry, School of Dentistry, National Taiwan University, Taipei City 100, Taiwan.ORCID 0000-0002-8378-5880
National Taiwan University · TWUniversity of Michigan · US

Funding

Ministry of Science and Technology 108-2314-B-002-038-MY3; 110-2314-B-002-104National Taiwan University Hospital 110-N4809; 110-S4947NIH HHS R01DE027675; R56DE015846
6 · The paper itself

Abstract

Familial tooth agenesis (FTA), distinguished by developmental failure of selected teeth, is one of the most prevalent craniofacial anomalies in humans. Mutations in genes involved in WNT/β-catenin signaling, including

Indexed as

digenic inheritanceexome sequencinggenetic mutationhypodontiaincomplete penetranceoligodontiaprecision medicinetooth developmentvariable expressivityWNT signaling

Identifiers

PMID34834569
PMCPMC8621929
OpenAlexW3214018074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.