ArticleJournal of personalized medicine2021
Longitudinal Study of the Association between General Anesthesia and Increased Risk of Developing Dementia.
Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Risk of dementia in older patients with different anesthesia: a systematic review and meta-analysis of cohort studies.BMC geriatrics · 2025Pooled it
- Association of General Anesthesia Exposure with Cognitive Outcomes in Older Adults: A Cross-Sectional Study in a Korean Cohort.Journal of clinical medicine · 2026Article
- The impact of surgery with general anesthesia on cognitive function and putamen volume: a cross-sectional study among older adults.Frontiers in aging neuroscience · 2024Article
- Tetra-block: ultrasound femoral, lateral femoral-cutaneous, obturator, and sciatic nerve blocks in lower limb anesthesia: a case series.Journal of medical case reports · 2023Article
- Dementia risk after major elective surgery based on the route of anaesthesia: A propensity score-matched population-based cohort study.EClinicalMedicine · 2023Article
- Risk of Burning Mouth Syndrome in Patients with Migraine: A Nationwide Cohort Study.Journal of personalized medicine · 2022Article
- Risk of Dementia According to Surgery Type: A Nationwide Cohort Study.Journal of personalized medicine · 2022Article
- Evaluating the dementia risk associated with anesthesia and surgery: A comprehensive systematic review and meta-analysis.Saudi journal of anaesthesiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The association between exposure to general anesthesia (GA) and the risk of dementia is still undetermined. To investigate a possible link to the development of dementia in older people who have undergone GA, we analyzed nationwide representative cohort sample data from the Korean National Health Insurance Service. The study cohort comprised patients over 55 years of age who had undergone GA between January 2003 and December 2004 and consisted of 3100 patients who had undergone GA and 12,400 comparison subjects who had not received anesthesia. After the nine-year follow-up period, we found the overall incidence of dementia was higher in the patients who had undergone GA than in the comparison group (10.5 vs. 8.8 per 1000 person-years), with the risk being greater for women (adjusted HR of 1.44; 95% CI, 1.19-1.75) and those with comorbidities (adjusted HR of 1.39; 95% CI, 1.18-1.64). Patients who underwent GA showed higher risks for Alzheimer's disease and vascular dementia (adjusted HR of 1.52; 95% CI, 1.27-1.82 and 1.64; 95% CI, 1.15-2.33, respectively). This longitudinal study using a sample cohort based on a nationwide population sample demonstrated a significant positive association between GA and dementia, including Alzheimer's disease and vascular dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.