Evidence map›Paper›PMID 34834493›Full record

ReviewJournal of personalized medicine2021

Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis.

Daniel A Rossignol, Richard E Frye

Erratum issuedOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. ACMT Position Statement: Current Evidence Does Not Support Routine Use of Leucovorin for Autism Spectrum Disorder.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2026
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. A Developmental Neuroimmune Cascade Model of Autism Spectrum Disorder.International journal of molecular sciences · 2026
    Review
  11. Natural Molecules for Brain Health and Resilience.International journal of molecular sciences · 2026
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Folate in autism neurodevelopment.Frontiers in nutrition · 2026
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Daniel A RossignolRossignol Medical Center, 24541 Pacific Park Drive, Suite 210, Aliso Viejo, CA 92656, USA.ORCID 0000-0002-4405-8664
Richard E FryeBarrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ 85016, USA.ORCID 0000-0003-4442-2937
Barrow Neurological Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cerebral folate receptor alpha (FRα) transports 5-methyltetrahydrofolate (5-MTHF) into the brain; low 5-MTHF in the brain causes cerebral folate deficiency (CFD). CFD has been associated with autism spectrum disorders (ASD) and is treated with

Indexed as

autism spectrum disordercerebral folate deficiencyfolate receptor alpha autoantibodiesfolinic acidleucovorin

Identifiers

PMID34834493
PMCPMC8622150
OpenAlexW3210385559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.