Evidence map›Paper›PMID 34834492›Full record

ArticleJournal of personalized medicine2021

Role of Sex on the Genetic Susceptibility to Childhood Asthma in Latinos and African Americans.

Antonio Espuela-Ortiz, Esther Herrera-Luis, Fabián Lorenzo-Díaz, Donglei Hu, Celeste Eng, Jesús Villar, Jose R Rodriguez-Santana, Esteban G Burchard, María Pino-Yanes

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Sex, hormones, and lung health.Physiological reviews · 2026
    Review
  2. The Effects of SNPs in theVeterinary medicine international · 2026
    Article
  3. Review
  4. Sex differences in sociodemographic, clinical, and laboratory variables in childhood asthma: A birth cohort study.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Antonio Espuela-OrtizGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain.ORCID 0000-0003-0572-9549
Esther Herrera-LuisGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain.
Fabián Lorenzo-DíazGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain.
Donglei HuDepartment of Medicine, University of California San Francisco, San Francisco, CA 94158, USA.
Celeste EngDepartment of Medicine, University of California San Francisco, San Francisco, CA 94158, USA.
Jesús VillarCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0001-5687-3562
Jose R Rodriguez-SantanaCentro de Neumología Pediátrica, San Juan 00917, Puerto Rico.
Esteban G BurchardDepartment of Medicine, University of California San Francisco, San Francisco, CA 94158, USA.
María Pino-YanesGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain.ORCID 0000-0003-0332-437X
Universidad de La Laguna · ESUniversity of California, San Francisco · USCentro de Neumologia Pediatrica · PRInstituto de Salud Carlos III · ES

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3M
Social Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2012 to 2016
$6.4M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
SF BUILD: Enabling Students to Represent in ScienceRL5GM118984 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2023
$5.2M
Optimizing imputation for diverse populations in a distributed frameworkU01HG009080 · NHGRI · STANFORD UNIVERSITY · PI KENNY, EIMEAR ELIZABETH · 2016 to 2020
$5.2M
Genetic Control of Airway Epithelium Gene Expression in Childhood AsthmaticsR01HL128439 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2015 to 2019
$3.1M
Gene-Environment Analyses of Early Life Exposures and Asthma in Ethnically Diverse ChildrenR21ES024844 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ, GAUDERMAN, WILLIAM JAMES · 2015 to 2017
$509k
American Asthma FoundationEuropean Regional Development Fund from the European Union SAF2017-83417RHarry Wm. and Diana V. Hind Distinguished Professorship in Pharmaceutical Sciences IIMICIU/ULL M-ULLNational Heart Lung and Blood Institute R01HL117004 and X01HL134589National Heart Lung and Blood Institute R01HL128439, R01HL135156, R01HL141992, and R01HL141845NCATS NIH HHS UL1 TR001872NHGRI NIH HHS U01HG009080NIEHS NIH HHS R01ES015794NIEHS NIH HHS R21ES24844NIGMS NIH HHS RL5 GM118984NIGMS NIH HHS RL5GM118984NIMHD NIH HHS P60MD006902, R01MD010443, and R56MD013312Robert Wood Johnson Foundation Amos Medical Faculty Development ProgramSandler FoundationSpanish Ministry of Science, Innovation, and Universities PRE2018-083837Spanish Ministry of Science, Innovation, and Universities RYC-2015-17205Spanish Ministry of Science, Innovation, and Universities SAF2017-83417RState Research Agency SAF2017-83417RTobacco-Related Disease Research Program 24RT-0025 and 27IR-0030
6 · The paper itself

Abstract

Asthma is a respiratory disease whose prevalence changes throughout the lifespan and differs by sex, being more prevalent in males during childhood and in females after puberty. In this study, we assessed the influence of sex on the genetic susceptibility to childhood asthma in admixed populations. Sex-interaction and sex-stratified genome-wide association studies (GWAS) were performed in 4291 Latinos and 1730 African Americans separately, and results were meta-analyzed. Genome-wide (

Indexed as

asthmaGWASHispanicminority populationsex interactionsex-stratified

Identifiers

PMID34834492
PMCPMC8625344
OpenAlexW3209669212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.