Evidence map›Paper›PMID 34834478›Full record

ArticleJournal of personalized medicine2021

The 2-Year Leakage Index and Quantitative Microaneurysm Results of the RECOVERY Study: Quantitative Ultra-Widefield Findings in Proliferative Diabetic Retinopathy Treated with Intravitreal Aflibercept.

Amy S Babiuch, Charles C Wykoff, Sari Yordi, Hannah Yu, Sunil K Srivastava, Ming Hu, Thuy K Le, Leina Lunasco, Jamie Reese, Muneeswar G Nittala and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. MAGIC: Study Design and Rationale for the Phase 2 Clinical Trial of Faricimab for Non-Proliferative Diabetic Retinopathy.Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde · 2026
    Trial
  2. Article
  3. Observational
  4. Article
  5. Age-Related Macular Degeneration and Diabetic Retinopathy.Journal of personalized medicine · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Amy S BabiuchCole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Charles C WykoffRetina Consultants of Texas, Kingwood, TX 77339, USA.
Sari YordiThe Tony and Leona Campane Center for Excellence for Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Hannah YuRetina Consultants of Texas, Kingwood, TX 77339, USA.
Sunil K SrivastavaCole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Ming HuThe Tony and Leona Campane Center for Excellence for Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA.ORCID 0000-0003-0987-2916
Thuy K LeThe Tony and Leona Campane Center for Excellence for Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Leina LunascoThe Tony and Leona Campane Center for Excellence for Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA.ORCID 0000-0003-3403-7429
Jamie ReeseCole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Muneeswar G NittalaDoheny Eye Institute, Los Angeles, CA 90033, USA.
SriniVas R SaddaDoheny Eye Institute, Los Angeles, CA 90033, USA.
Justis P EhlersCole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Cleveland Clinic · USDoheny Eye Institute · USMethodist Hospital · US

Funding

Intraoperative Optical Coherence Tomography for Ophthalmic SurgeryK23EY022947 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI EHLERS, JUSTIS · 2013 to 2017
$1.0M
NEI NIH HHS K23-EY022947-01A1Regeneron RegeneronResearch to Prevent Blindness Cole Eye Institutional Grant
6 · The paper itself

Abstract

Eyes with proliferative diabetic retinopathy (PDR) have been shown to improve in the leakage index and microaneurysm (MA) count after intravitreal aflibercept (IAI) treatment. The authors investigated these changes via automatic segmentation on ultra-widefield fluorescein angiography (UWFA). Forty subjects with PDR were randomized to receive either 2 mg IAI every 4 weeks (Arm 1) or every 12 weeks (Arm 2) through Year 1. After Year 1, Arm 1 switched to quarterly IAI and Arm 2 to monthly IAI through Year 2. By Year 2, the Arm 1 leakage index decreased by 43% from Baseline (

Indexed as

anti-vascular endothelial growth factordiabetic macular edemadiabetic retinopathyintravitreal afliberceptleakage indexmicroaneurysmsneovascularizationoptical coherence tomographyultra-widefield fluorescein angiography

Identifiers

PMID34834478
PMCPMC8619795
OpenAlexW3209345789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.