Evidence map›Paper›PMID 34834466›Full record

ArticleJournal of personalized medicine2021

Online Left-Hemispheric In-Phase Frontoparietal Theta tACS for the Treatment of Negative Symptoms of Schizophrenia.

Chuan-Chia Chang, Cathy Chia-Yu Huang, Yong-An Chung, Jooyeon Jamie Im, Yen-Yue Lin, Chin-Chao Ma, Nian-Sheng Tzeng, Hsin-An Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Transcranial Alternating Current Stimulation (tACS) and Its Role in Schizophrenia: A Scoping Review.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chuan-Chia ChangDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Cathy Chia-Yu HuangDepartment of Life Sciences, National Central University, Taoyuan 32001, Taiwan.
Yong-An ChungDepartment of Nuclear Medicine, College of Medicine, The Catholic University of Korea, Seoul 21431, Korea.
Jooyeon Jamie ImDepartment of Nuclear Medicine, College of Medicine, The Catholic University of Korea, Seoul 21431, Korea.
Yen-Yue LinDepartment of Life Sciences, National Central University, Taoyuan 32001, Taiwan.ORCID 0000-0001-6885-2523
Chin-Chao MaDepartment of Psychiatry, Tri-Service General Hospital Beitou Branch, National Defense Medical Center, Taipei 114, Taiwan.
Nian-Sheng TzengDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Hsin-An ChangDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0001-5572-7109

Funding

Medical Affairs Bureau, Ministry of National Defense MND-MAB-110-071Ministry of Science and Technology of the Taiwanese Government MOST 109-2628-B-016-003Tri-Service General Hospital TSGH-D-109134 and TSGH-BT-A-109001
6 · The paper itself

Abstract

Negative symptoms represent an unmet need for schizophrenia treatment. The effect of theta frequency transcranial alternating current stimulation (theta-tACS) applied during working memory (WM) tasks on negative symptoms has not been demonstrated as of yet. We conducted a randomized, double-blind, sham-controlled trial of 36 stabilized schizophrenia patients, randomized to receive either twice daily, 6 Hz 2 mA, 20 min sessions of in-phase frontoparietal tACS or sham for five consecutive weekdays. Participants were concurrently engaged in WM tasks during stimulation. The primary outcome measure was the change over time in the Positive and Negative Syndrome Scale (PANSS) negative subscale score measured from baseline through to the 1-month follow-up. Secondary outcome measures were other symptom clusters, neurocognitive performance, and relevant outcomes. The intention-to-treat analysis demonstrated greater reductions in PANSS negative subscale scores at the end of stimulation in the active (-13.84%) than the sham (-3.78%) condition, with a large effect size (Cohen's d = 0.96,

Indexed as

frontoparietal theta couplingnegative symptomsonline stimulationschizophreniatranscranial alternating current stimulationworking memory

Identifiers

PMID34834466
PMCPMC8625275

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.