Evidence map›Paper›PMID 34834458›Full record

ArticleJournal of personalized medicine2021

Myocarditis and Pericarditis following COVID-19 Vaccination: Inequalities in Age and Vaccine Types.

Minghui Li, Jing Yuan, Gang Lv, Jacob Brown, Xiangxiang Jiang, Zhiqiang Kevin Lu

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. COVID-19 vaccine induced myocarditis in young males: A systematic review.European journal of clinical investigation · 2023
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. COVID-19 Vaccines in Children.Journal of clinical medicine · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Myocarditis following Coronavirus vaccination.Clinical immunology communications · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. COVID-19 Vaccines and Myopericarditis: A Nuanced Story.Journal of personalized medicine · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Minghui LiDepartment of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Jing YuanDepartment of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai 201203, China.ORCID 0000-0003-0906-1822
Gang LvDepartment of General Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing 100091, China.
Jacob BrownCollege of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.ORCID 0000-0003-3545-5112
Xiangxiang JiangSchool of Public Health, Nanjing Medical University, Nanjing 210029, China.
Zhiqiang Kevin LuCollege of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.
University of South Carolina · USChinese PLA General Hospital · CNFudan University · CNNanjing Medical University · CNUniversity of Tennessee Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increasing number of myocarditis/pericarditis incidences has been reported after coronavirus disease-19 (COVID-19) vaccination in adolescents and young adults. This study was designed to investigate the incidence rate of-and risk for-myocarditis and pericarditis following COVID-19 vaccination in the United States according to age and vaccine type. This study used the Vaccine Adverse Events Reporting System (VAERS) from 11 December 2020 to 13 August 2021. A population-based data mining approach was performed based on the reporting odds ratio (ROR). Adverse events of myocarditis and pericarditis following COVID-19 vaccination were rare, with an incidence rate of 5.98 (95% CI = 5.73-6.24) cases per million doses administered. The incidence rate was higher in adolescents and after the administration of the second dose of messenger RNA (mRNA) vaccines. Overall, two mRNA vaccines were significantly associated with increased risks for myocarditis/pericarditis (mRNA-1273 (Moderna): ROR = 2.91, 95% CI = 2.21-3.83; BNT162b2 (Pfizer-BioNTech): ROR = 5.37, 95% CI = 4.10-7.04) compared to all other vaccines from VAERS. The viral vector vaccine of Ad26.COV2.S (Janssen) was not associated with signals of myocarditis/pericarditis (ROR = 1.39; 95% CI = 0.99-1.97). This study found increased risks for myocarditis/pericarditis following mRNA COVID-19 vaccines. For patients at high risk for myocarditis/pericarditis or with myocardial injuries, the viral vector vaccine may be an alternative for consideration.

Indexed as

ageCOVID-19 vaccinemRNA vaccinemyocarditispericarditis

Identifiers

PMID34834458
PMCPMC8624452
OpenAlexW3210772760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.