Evidence map›Paper›PMID 34834414›Full record

ArticleJournal of personalized medicine2021

A Sneak-Peek into the Physician's Brain: A Retrospective Machine Learning-Driven Investigation of Decision-Making in TAVR versus SAVR for Young High-Risk Patients with Severe Symptomatic Aortic Stenosis.

Ena Hasimbegovic, Laszlo Papp, Marko Grahovac, Denis Krajnc, Thomas Poschner, Waseem Hasan, Martin Andreas, Christoph Gross, Andreas Strouhal, Georg Delle-Karth and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Data-driven decision making in patient management: a systematic review.BMC medical informatics and decision making · 2025
    Pooled it
  2. Pooled it
  3. Review
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  9. Automated data preparation forFrontiers in oncology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Ena HasimbegovicDivision of Cardiac Surgery, Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Laszlo PappCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-9049-9989
Marko GrahovacDivision of Nuclear Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Denis KrajncCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-1786-4297
Thomas PoschnerDivision of Cardiac Surgery, Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-0374-8375
Waseem HasanFaculty of Medicine, Imperial College London, London SW7 2AZ, UK.
Martin AndreasDivision of Cardiac Surgery, Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Christoph GrossDivision of Cardiac Surgery, Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-1583-5783
Andreas StrouhalDepartment of Cardiovascular Surgery, Hospital Hietzing and the Karl Landsteiner Institute for Cardiovascular and Critical Care Research, 1090 Vienna, Austria.
Georg Delle-KarthDepartment of Cardiovascular Surgery, Hospital Hietzing and the Karl Landsteiner Institute for Cardiovascular and Critical Care Research, 1090 Vienna, Austria.
Martin GrabenwögerFaculty of Medicine, Sigmund Freud University, 1090 Vienna, Austria.
Christopher AdlbrechtDepartment of Cardiovascular Surgery, Hospital Hietzing and the Karl Landsteiner Institute for Cardiovascular and Critical Care Research, 1090 Vienna, Austria.
Markus MachDivision of Cardiac Surgery, Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-3184-4914
Medical University of Vienna · ATKlinik Hietzing · ATImperial College London · GBKarl Landsteiner Society · ATSigmund Freud Privatuniversität Wien · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcatheter aortic valve replacement (TAVR) has rapidly become a viable alternative to the conventional isolated surgical aortic valve replacement (iSAVR) for treating severe symptomatic aortic stenosis. However, data on younger patients is scarce and a gap exists between data-based recommendations and the clinical use of TAVR. In our study, we utilized a machine learning (ML) driven approach to model the complex decision-making process of Heart Teams when treating young patients with severe symptomatic aortic stenosis with either TAVR or iSAVR and to identify the relevant considerations. Out of the considered factors, the variables most prominently featured in our ML model were congestive heart failure, established risk assessment scores, previous cardiac surgeries, a reduced left ventricular ejection fraction and peripheral vascular disease. Our study demonstrates a viable application of ML-based approaches for studying and understanding complex clinical decision-making processes.

Indexed as

aortic stenosisheart teamiSAVRmachine learningTAVITAVR

Identifiers

PMID34834414
PMCPMC8622882
OpenAlexW3211168227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.