Evidence map›Paper›PMID 34834387›Full record

ReviewPharmaceutics2021

Smart Nanotherapeutics and Lung Cancer.

Mohammad Doroudian, Mohammad H Azhdari, Nima Goodarzi, David O'Sullivan, Seamas C Donnelly

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Current trends in exosomes as therapeutic drug delivery systems.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Targeting breast cancer: the promise of phage-based nanomedicines.Breast cancer research and treatment · 2025
    Review
  9. Review
  10. Role of Nanoformulations in the Treatment of Lung Cancer.Recent patents on nanotechnology · 2025
    Review
  11. Review
  12. Review
  13. Role of STING in the treatment of non-small cell lung cancer.Cell communication and signaling : CCS · 2024
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohammad DoroudianSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland.ORCID 0000-0002-2933-9898
Mohammad H AzhdariDepartment of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi University, Tehran 15719-14911, Iran.ORCID 0000-0001-7752-090X
Nima GoodarziDepartment of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi University, Tehran 15719-14911, Iran.ORCID 0000-0002-0874-2135
David O'SullivanSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland.
Seamas C DonnellySchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer is a significant health problem worldwide. Unfortunately, current therapeutic strategies lack a sufficient level of specificity and can harm adjacent healthy cells. Consequently, to address the clinical need, novel approaches to improve treatment efficiency with minimal side effects are required. Nanotechnology can substantially contribute to the generation of differentiated products and improve patient outcomes. Evidence from previous research suggests that nanotechnology-based drug delivery systems could provide a promising platform for the targeted delivery of traditional chemotherapeutic drugs and novel small molecule therapeutic agents to treat lung cancer cells more effectively. This has also been found to improve the therapeutic index and reduce the required drug dose. Nanodrug delivery systems also provide precise control over drug release, resulting in reduced toxic side effects, controlled biodistribution, and accelerated effects or responses. This review highlights the most advanced and novel nanotechnology-based strategies, including targeted nanodrug delivery systems, stimuli-responsive nanoparticles, and bio-nanocarriers, which have recently been employed in preclinical and clinical investigations to overcome the current challenges in lung cancer treatments.

Indexed as

combination therapylung cancernanochemotherapeuticsnanodrug deliverynanomedicinenanotechnologynanotherapeuticssmart nanoparticlestargeted drug delivery

Identifiers

PMID34834387
PMCPMC8619749

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.