Evidence map›Paper›PMID 34834382›Full record

ArticlePharmaceutics2021

Expression of Chimeric HPV-HIV Protein L1P18 in

Yoshiki Eto, Narcís Saubi, Pau Ferrer, Joan Joseph-Munné

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Yoshiki EtoDepartment of Microbiology, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
Narcís SaubiDepartment of Microbiology, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.ORCID 0000-0001-5493-1044
Pau FerrerDepartment of Chemical, Biological and Environmental Engineering, School of Engineering, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.ORCID 0000-0002-5287-4127
Joan Joseph-MunnéDepartment of Microbiology, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
Universitat Autònoma de Barcelona · ESVall d'Hebron Hospital Universitari · ESVall d'Hebron Institut de Recerca · ES

Funding

Centre for Industrial Technological Development IDI-20200297Horizon 2020 681137Instituto de Salud Carlos III FIS PI14/00494Instituto de Salud Carlos III FIS PI20/00217Instituto de Salud Carlos III RETIC-RIS RD12/0017
6 · The paper itself

Abstract

Currently, three human papillomavirus (HPV) vaccines are already licensed and all of them are based on virus-like particles (VLPs) of HPV L1 capsid protein but not worldwide accessible. While about 38.0 million people were living with HIV in 2019, only 68% of HIV-infected individuals were accessing antiretroviral therapy as of the end of June 2020 and there is no HIV vaccine yet. Therefore, safe, effective, and affordable vaccines against those two viruses are immediately needed. Both HPV and HIV are sexually transmitted infections and one of the main access routes is the mucosal genital tract. Thus, the development of a combined vaccine that would protect against HPV and HIV infections is a logical effort in the fight against these two major global pathogens. In this study, a recombinant

Indexed as

chimericHIVHPVPichia pastorispurificationvaccinevirus-like particleyeast

Identifiers

PMID34834382
PMCPMC8622379
OpenAlexW3215059282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.